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Internet delivered cognitive behavior therapy for antenatal depression: A randomised controlled trial
Centre for Psychiatry Research, Department of Clinical Neuroscience, Karolinska Institutet, Sweden.
Department of Clinical Sciences, Psychiatry, Umeå University, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. University Health Care Research Centre.ORCID iD: 0000-0001-9500-7763
Department of Children and Women, Karolinska University Hospital, Huddinge, Sweden.
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2017 (English)In: Journal of Affective Disorders, ISSN 0165-0327, E-ISSN 1573-2517, Vol. 221, 56-64 p.Article in journal (Refereed) Published
Abstract [en]

Major depression occurs in 5-10% of pregnancies and is associated with many negative effects for mother and child, yet treatment options are scarce. To our knowledge, this is the first published randomised controlled trial on Internet delivered Cognitive Behavior Therapy (ICBT) for this group.

Objective: To test the efficacy of a pregnancy adapted version of an existing 10-week ICBT-program for depression as well as assessing acceptability and adherence.

Design: Randomised controlled trial.

Setting: Online and telephone.

Population or sample: Self-referred pregnant women (gestational week 10-28 at intake) currently suffering from major depressive disorder.

Methods: 42 pregnant women (gestational week 12-28) with major depression were randomised to either treatment as usual (TAU) provided at their antenatal clinic or to ICBT as an add-on to usual care.

Main outcome measures: The primary outcome was depressive symptoms measured with the Montgomery-Asberg depression rating scale-self report (MADRS-S). The Edinburgh Postnatal Depression Scale and measures of anxiety and sleep were used. Credibility, satisfaction, adherence and utilization were also assessed.

Results: The ICBT group had significantly lower levels of depressive symptoms post treatment (p < 0.001, Hedges g = 1.21) and were more likely to be responders (i.e. achieve a statistically reliable improvement) (RR = 0.36; p = 0.004). Measures of treatment credibility, satisfaction, utilization, and adherence were comparable to implemented ICBT for depression.

Limitations: Small sample size and no long-term evaluation.

Conclusion: Pregnancy adapted ICBT for antenatal depression is feasible, acceptable and efficacious. These results need to be replicated in larger trials to validate these promising findings.

Place, publisher, year, edition, pages
Amsterdam, Netherlands: Elsevier, 2017. Vol. 221, 56-64 p.
Keyword [en]
Depression, Pregnancy, Cognitive behavior therapy, Internet, Antenatal depression, Psychotherapy, Perinatal mental health, ehealth, Online
National Category
Neurology Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-59416DOI: 10.1016/j.jad.2017.06.013ISI: 000406464200009PubMedID: 28628768Scopus ID: 2-s2.0-85020791703OAI: oai:DiVA.org:oru-59416DiVA: diva2:1137103
Funder
Swedish Research Council, DNR 521-2012-3466
Note

Funding Agencies:

Karolinska Institutet  

Stockholm City Council  

Umeå University  

Västerbotten County Council (ALF) 

Available from: 2017-08-30 Created: 2017-08-30 Last updated: 2017-11-02Bibliographically approved

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