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Decreased expression of the mitochondrial solute carrier SLC25A43 in basal cell carcinoma compared with healthy skin
Department of Dermatology, Örebro University Hospital, Örebro, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Clinical Research Laboratory.ORCID iD: 0000-0002-7498-7157
School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Örebro University, School of Medical Sciences. Department of Dermatology, Örebro University Hospital, Örebro, Sweden.
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2017 (English)In: Oncology Letters, ISSN 1792-1074, E-ISSN 1792-1082, Vol. 14, no 2, 2218-2222 p.Article in journal (Refereed) Published
Abstract [en]

Basal cell carcinoma is the most common type of cancer in fair-skinned individuals, and its incidence is rapidly increasing. The aim of the present study was to investigate the gene and protein expression of the mitochondrial solute carrier family 25 member 43 (SLC25A43) in basal cell carcinoma. SLC25A43 has previously been identified to be genetically altered and associated with cell proliferation in human epidermal growth factor receptor 2-positive breast cancer. However, the knowledge about SLC25A43 is limited, and its role in other cancers is unknown. The SLC25A43 gene and protein expression was analysed in 14 basal cell carcinomas and healthy skin samples from the same individuals by quantitative polymerase chain reaction and immunohistochemistry, respectively. The results demonstrated a significantly lower (>= 50%) SLC25A43 gene expression in all carcinomas compared with that in healthy skin. In addition, SLC25A43 protein expression was absent in >90% of all visual fields in the basal cell carcinomas, and the H-score was significantly lower in tumours compared with the adjacent epidermis. These results demonstrate that SLC25A43 expression is altered at the gene and protein levels in basal cell carcinoma. The underlying mechanisms and the clinical relevance of these data must be elucidated in additional experimental and clinical studies.

Place, publisher, year, edition, pages
Spandidos Publications , 2017. Vol. 14, no 2, 2218-2222 p.
Keyword [en]
basal cell carcinoma, non-melanoma skin cancer, solute carrier family 25 member 43, quantitative polymerase chain reaction, immunohistochemistry
National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:oru:diva-60602DOI: 10.3892/ol.2017.6452ISI: 000407904600140PubMedID: 28781661Scopus ID: 2-s2.0-85021770910OAI: oai:DiVA.org:oru-60602DiVA: diva2:1138436
Note

Funding Agency:

Nyckelfonden, Örebro University Hospital Cancer Foundation, Sweden  OLL-255231

Available from: 2017-09-05 Created: 2017-09-05 Last updated: 2017-10-16Bibliographically approved

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Göthlin Eremo, AnnaLindberg, MagnusTina, Elisabet

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