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Expression of LRIG proteins as possible prognostic factors in primary vaginal carcinoma
Department of Women’s and Children ’s Health, Karolinska Institutet, Stockholm, Sweden; Region Västmanland – Uppsala University, Centre for Clinical Research, Hospital of Västmanland Västerås, Västerås, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Laboratory Medicine.
Department of Radiation Sciences, Umeå University, Umeå , Sweden.
Department of Radiation Sciences, Umeå University, Umeå , Sweden.
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2017 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 8, e0183816Article in journal (Refereed) Published
Abstract [en]

Background: Primary vaginal carcinoma (PVC) is a rare malignancy. Established prognostic factors include tumour stage and age at diagnosis. The leucine-rich repeats and immunoglobuline-like domains (LRIG)-1 protein functions as a tumour suppressor, but less is known about the functions of LRIG2 and LRIG3. The present study aimed to evaluate the expression of LRIG proteins and analyse their possible associations with clinical characteristics and survival in a cohort of PVC patients.

Methods: We used immunohistochemistry to investigate LRIG1, LRIG2, and LRIG3 expression in tumour samples from a consecutive cohort of 70 PVC patients. The association between LRIG protein expression and clinical characteristics and cancer-specific survival was investigated using univariate and multivariate analyses.

Results: The majority of PVC patients (72%) had > 50% LRIG1-and LRIG2-positive cells, and no or low LRIG3-positive cells. HPV status was significantly correlated with LRIG1 expression (p = 0.0047). Having high LRIG1 expression was significantly correlated with superior cancer-specific survival in univariate and multivariate analyses. LRIG2 and LRIG3 expression did not significantly correlate with clinical characteristics or survival.

Conclusion: LRIG1 expression might be of interest as a prognostic marker in PVC patients, whereas the role of LRIG2 and LRIG3 expression remains to be clarified.

Place, publisher, year, edition, pages
Public Library of Science , 2017. Vol. 12, no 8, e0183816
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-61041DOI: 10.1371/journal.pone.0183816ISI: 000408370700059PubMedID: 28841699OAI: oai:DiVA.org:oru-61041DiVA: diva2:1142258
Funder
Swedish Cancer Society, 070623 CAN 2007/1044 11 0544 CAN 2011/471Swedish Research Council, 521-2008-2899
Note

Funding Agencies:

Karolinska Institutet Cancer Strategic Grants  5888/05-722

Stockholm County Council  20130097 

Region Örebro County  OLL-526041 

Lion's Cancer Research Foundation  

University of Umeå  

Gustaf V Jubilee Fund  154022 

Region Västmanland - Uppsala University Centre for Clinical Research Hospital of Västmanland Västerås 

Available from: 2017-09-19 Created: 2017-09-19 Last updated: 2017-09-19Bibliographically approved

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