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Do PCDD/PCDF standard solutions used in dioxin analysis pose a risk as potentially acutely toxic to lab personnel?
EU Reference Laboratory for Dioxins and PCBs in Feed and Food, Chemisches und Veterinäruntersuchungsamt, Freiburg, Germany.
Department of Environmental Toxicology, University of California, Davis CA, United States.
Örebro University, School of Science and Technology. (MTM Research Centre)ORCID iD: 0000-0003-1496-9245
Chemisches und Veterinäruntersuchungsamt Münsterland-Emscher-Lippe (CVUA-MEL), Münster, Germany.
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2017 (English)In: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 185, 489-498 p.Article in journal (Refereed) Published
Abstract [en]

Laboratory safety requires protecting personnel from chemical exposures. Working with stock solutions of polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/PCDFs) in routine analysis of feed and food with bioanalytical or physicochemical methods raises some concerns. Since PCDD/PCDFs are considered as possibly acutely toxic, the potential risks were evaluated to determine whether supervision of their use is necessary. Based on LD50-data for oral or dermal intake, hazard classification of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) as a substance (category 1) and in commercially available TCDD standard solutions (category 4) is different. As worst case exposure scenario during routine laboratory work it was assumed that a dose of 100 ng TCDD gets onto the skin and is absorbed. This would result in the total body burden of a 70 kg person with 15 kg fat increasing from 10 (upper range of current background levels) to similar to 17 pg of toxic equivalents (TEQs) of PCDD/PCDFs per g lipid, a level commonly observed over past decades. Chloracne, the main acute effect occurring weeks after exposure, is observed at much higher blood concentrations than estimated from accidental laboratory exposure. Immunotoxicity, developmental effects and other toxic effects may occur at lower blood levels, but require longer periods to develop. Since acute toxic symptoms don't occur within an "8 h acute time window", no supervision is necessary when working with standard solutions in routine analysis. Nevertheless, precautionary measures are needed regarding long-term adverse health effects and appropriate workplace conditions must exist to ensure that additional occupational exposure to PCDD/PCDFs by laboratory personnel is negligible.

Place, publisher, year, edition, pages
Oxford, UK: Elsevier, 2017. Vol. 185, 489-498 p.
Keyword [en]
PCDD/PCDF, Standard solutions, Acute toxicity, Laboratory incidents, Safety partnerships
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:oru:diva-61033DOI: 10.1016/j.chemosphere.2017.07.021ISI: 000408597300056PubMedID: 28715759Scopus ID: 2-s2.0-85023610689OAI: oai:DiVA.org:oru-61033DiVA: diva2:1142374
Conference
18th International Conference on Heavy Metals in the Environment (ICHMET), Ghent University, Ghent, Belgium, September 12-15, 2016
Available from: 2017-09-19 Created: 2017-09-19 Last updated: 2017-10-13Bibliographically approved

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