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Brainstem Auditory Evoked Potentials for diagnosing Autism Spectrum Disorder, ADHD and Schizophrenia Spectrum Disorders in adults: A blinded study
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Järva psychiatric out-patient clinic, Praktikertjänst AB, Stockholm, Sweden.
Örebro University, School of Medical Sciences. University Health Care Research Centre, Örebro University, Örebro, Sweden.ORCID iD: 0000-0001-6726-7787
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Örebro University, School of Medical Sciences. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; University Health Care Research Centre, Örebro University, Örebro, Sweden.ORCID iD: 0000-0002-3587-6075
2017 (English)In: Psychiatry Research, ISSN 0165-1781, E-ISSN 1872-7123, Vol. 257, 21-26 p.Article in journal (Refereed) Published
Abstract [en]

The aim of the present study was to examine the clinical utility of complex auditory brainstem response (c-ABR) and investigate if c-ABR is helpful in the diagnostic procedure. Thirty-one adult psychiatric patients, thoroughly diagnosed with autism spectrum disorder (ASD) (n=16), ADHD (n=8), or schizophrenia spectrum disorder (SSD) (n=7) and 15 healthy controls (HC), were blindly assessed with SensoDetect BERA. This c-ABR correctly identified psychiatric diagnoses in 4 patients (13%) and provided partially correct diagnoses in 11 more patients. Of the 15 HC, 6 were misclassified as psychiatric patients. The Cohen´s kappa coefficient (κ) was substantial for HC (κ=0.67), fair for SSD (κ=0.37), slight for ADHD (κ=0.09) and without agreement in ASD (κ=-0.03). In conclusion, we found the c-ABR method unhelpful and unreliable as a tool in clinical diagnostics.

Place, publisher, year, edition, pages
Clare, Ireland: Elsevier, 2017. Vol. 257, 21-26 p.
Keyword [en]
Auditory brainstem response, double-blind method, mental disorder
National Category
Psychiatry Neurology
Identifiers
URN: urn:nbn:se:oru:diva-61468DOI: 10.1016/j.psychres.2017.06.085ISI: 000413385300004PubMedID: 28710948Scopus ID: 2-s2.0-85022338791OAI: oai:DiVA.org:oru-61468DiVA: diva2:1149025
Funder
Swedish Research Council, K2012-62X -22130-04-6
Note

Funding Agencies:

Praktikertjanst AB, Stockholm, Sweden  

Stockholm County Council  20110307 

Karolinska Institutet  20110307 

Region Örebro County, Sweden 

Available from: 2017-10-13 Created: 2017-10-13 Last updated: 2017-12-06Bibliographically approved

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Humble, Mats B.Bejerot, Susanne

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