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A Walking Intervention Among Men With Prostate Cancer: A Pilot Study
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA.
Örebro University, School of Medical Sciences. (Clinical Epidemiology and Biostatistics)ORCID iD: 0000-0002-3649-2639
Department of Epidemiology, Boston University School of Public Health, Boston MA, USA.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA.
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2017 (English)In: Clinical Genitourinary Cancer, ISSN 1558-7673, E-ISSN 1938-0682, Vol. 15, no 6, p. e1021-e1028Article in journal (Refereed) Published
Abstract [en]

Men diagnosed with prostate cancer have increased risk of disease progression, cardiovascular events, and quality of life impairments. Men with a recent diagnosis randomly assigned to a walking group intervention maintained 10,000 steps per day and experienced improvement in cardiovascular biomarkers compared with usual care. A larger walking group intervention is needed to investigate its potential for improvement in longterm outcomes.

BACKGROUND: Men diagnosed with prostate cancer have increased risk for disease progression, cardiovascular events, and impairments in quality of life. This pilot study evaluated the feasibility of a randomized walking group intervention to improve quality of life, circulating biomarkers, and morbidity among men with newly diagnosed prostate cancer.

METHODS: Men were recruited at Örebro University Hospital, Sweden, and randomized to an 11-week walking group intervention (n = 21) or usual care (n = 20). The intervention included weekly 1-hour walking group sessions and maintenance of 10,000 steps/day. Outcomes were changes in body composition, clinical factors, biomarkers of cardiovascular health, and quality of life between baseline and end of study. Analysis of covariance was used to compare outcomes in each group adjusted for baseline values.

RESULTS: All 41 men randomized completed the 11-week trial. Men assigned to the intervention walked on average 10,644 steps/day, and 92% reported missing 2 or fewer sessions. Both groups experienced similar weight loss at 11 weeks. Men in the intervention had a significant adjusted mean change in high-density lipoprotein of 0.14 mmol/L (95% confidence interval [CI], 0.01-0.27; P = .04), and suggestive adjusted mean changes in low-density lipoprotein of -0.22 mmol/L (95% CI, -0.47 to 0.03; P = .08) and in systolic blood pressure of -8.5 mm Hg (95% CI, -21.2 to 4.2; P = .18), compared with the usual care group.

CONCLUSIONS: A walking group intervention among men with recent diagnosis of prostate cancer is feasible and potentially effective in improving cardiovascular health. A larger randomized trial of longer duration is required to elucidate its potential for improvement in longer term outcomes.

Place, publisher, year, edition, pages
New York, USA: Elsevier, 2017. Vol. 15, no 6, p. e1021-e1028
Keywords [en]
Biomarkers, Cardiovascular health, Exercise, Quality of life, Randomized trial
National Category
Cancer and Oncology Urology and Nephrology
Identifiers
URN: urn:nbn:se:oru:diva-60799DOI: 10.1016/j.clgc.2017.05.022ISI: 000417112200014PubMedID: 28668276Scopus ID: 2-s2.0-85021299019OAI: oai:DiVA.org:oru-60799DiVA, id: diva2:1149573
Note

Funding Agencies:

National Institutes of Health (NIH)  T32 ES 007069  T32 CA 09001 

Prostate Cancer Foundation (PCF)  

Available from: 2017-10-16 Created: 2017-10-16 Last updated: 2018-08-06Bibliographically approved

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Fall, KatjaAndrén, Ove

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