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A Randomized Controlled Trial Evaluating the Effects of Diosmin in the Treatment of Radicular Pain
Department of Orthopedic Surgery, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, China.
Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Pharmacology, Qianfo Hill Institute of Shandong Province, Jinan, China.
Department of International Training, PLA University of Science and Technology, Nanjing, China.
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2017 (English)In: BioMed Research International, ISSN 2314-6133, E-ISSN 2314-6141, article id 6875968Article in journal (Refereed) Published
Abstract [en]

Diosmin has been widely used to treat patients with vascular pain for its potent anti-inflammatory and analgesic effects. To evaluate the therapeutic effects of Diosmin in the treatment of radicular pain, we conducted an investigator-initiated, randomized, activecontrolled noninferiority trial between January 1, 2009, and December 1, 2010. Diosmin (50 mg/kg/day) was orally administered to treat the radicular pain in 150 patients for onemonth. Another 150 patientswith the same symptomwere given 20% 250 ml mannitol (1 g/kg/day) for 7 days and dexamethasone (10 mg/day) for 3 days intravenously guttae. Short-term relief and long-term relief were measured. Secondary outcomes include improvement in functional and psychological status, return to work, and reduction in antiinflammatory analgesic drugs intake. Patients treated with oral Diosmin achieved reduction in radicular pain. The total satisfaction rate of Diosmin group was 84.7% [95% confidence interval (CI): 77.9%, 90.0%], and the complete satisfaction rate was 50.7% (95% CI: 42.4%, 58.9%). No statistically significant difference was found between the Diosmin group and the active-control group regarding patient satisfaction. No adverse effects were found during the study period. Our study suggests that clinical application of Diosmin with a dose of 50 mg/kg/day might reduce the radicular pain. This trial is registered with ISRCTN97157037.

Place, publisher, year, edition, pages
Hindawi Publishing Corporation, 2017. article id 6875968
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Other Medical Biotechnology
Identifiers
URN: urn:nbn:se:oru:diva-61642DOI: 10.1155/2017/6875968ISI: 000412389100001OAI: oai:DiVA.org:oru-61642DiVA, id: diva2:1150209
Note

Funding Agencies:

National Natural Science Foundation of China  81271997  81401793 

Medical Science and Technology Development Foundation, Department of Health of Nanjing City  ZKX10007 

Postdoctoral Science Foundation of China  20100481130 

Medical Key Personnel Program of Jiangsu Province, China  RC2011150 

Available from: 2017-10-18 Created: 2017-10-18 Last updated: 2018-08-07Bibliographically approved

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