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Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort
Department of Psychiatry, Royal College of Surgeons in Ireland (RCSI), Beaumont Hospital, Dublin, Ireland; Institute of Food and Health, UCD School of Agriculture and Food Science, University College Dublin (UCD) Belfield, Dublin, Ireland.
Steno Diabetes Center, Gentofte, Denmark.
Steno Diabetes Center, Gentofte, Denmark.
Department of Psychiatry, Royal College of Surgeons in Ireland (RCSI), Beaumont Hospital, Dublin, Ireland.
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2017 (English)In: Translational Psychiatry, ISSN 2158-3188, E-ISSN 2158-3188, Vol. 7, article id e1240Article in journal (Refereed) Published
Abstract [en]

The identification of an early biomarker of psychotic disorder is important as early treatment is associated with improved patient outcome. Metabolomic and lipidomic approaches in combination with multivariate statistical analysis were applied to identify plasma alterations in children (age 11) (38 cases vs 67 controls) and adolescents (age 18) (36 cases vs 117 controls) preceeding or coincident with the development of psychotic disorder (PD) at age 18 in the Avon Longitudinal Study of Parents and Children (ALSPAC). Overall, 179 lipids were identified at age 11, with 32 found to be significantly altered between the control and PD groups. Following correction for multiple comparisons, 8 of these lipids remained significant (lysophosphatidlycholines (LPCs) LPC(18: 1), LPC(18: 2), LPC(20: 3); phosphatidlycholines (PCs) PC(32: 2; PC(34: 2), PC(36: 4), PC(0-34-3) and sphingomyelin (SM) SM(d18: 1/24: 0)), all of which were elevated in the PD group. At age 18, 23 lipids were significantly different between the control and PD groups, although none remained significant following correction for multiple comparisons. In conclusion, the findings indicate that the lipidome is altered in the blood during childhood, long before the development of psychotic disorder. LPCs in particular are elevated in those who develop PD, indicating inflammatory abnormalities and altered phospholipid metabolism. These findings were not found at age 18, suggesting there may be ongoing alterations in the pathophysiological processes from prodrome to onset of PD.

Place, publisher, year, edition, pages
Nature Publishing Group, 2017. Vol. 7, article id e1240
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Psychiatry
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URN: urn:nbn:se:oru:diva-61635DOI: 10.1038/tp.2017.211ISI: 000412092700002PubMedID: 28949339OAI: oai:DiVA.org:oru-61635DiVA, id: diva2:1150256
Note

Funding Agencies:

Wellcome  102215/2/13/2 

NIHR Bristol BRC  

Irish Health Research Board through a Clinician Scientist Award  

Health Research Board  HRA-POR-2013-282  HRB CSA 2012/8 

European Research Council  647783 

UK Medical Research Council  102215/2/13/2 

Available from: 2017-10-18 Created: 2017-10-18 Last updated: 2019-03-04Bibliographically approved

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Hyötyläinen, TuuliaOresic, Matej

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