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Health-Related Quality-of-Life after Laparoscopic Gastric Bypass Surgery with or Without Closure of the Mesenteric Defects: a Post-hoc Analysis of Data from a Randomized Clinical Trial
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Surgery.ORCID iD: 0000-0003-4958-1611
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Surgery.
Department of Surgery, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Department of Surgery, Ersta Hospital, Stockholm, Sweden; Department of Clinical Sciences, Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
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2018 (English)In: Obesity Surgery, ISSN 0960-8923, E-ISSN 1708-0428, Vol. 28, no 1, 31-36 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Mesenteric defect closure in laparoscopic gastric bypass surgery has been reported to reduce the risk for small bowel obstruction. Little is known, however, about the effect of mesenteric defect closure on patient-reported outcome. The aim of the present study was to see if mesenteric defect closure affects health-related quality-of-life (HRQoL) after laparoscopic gastric bypass.

METHODS: Patients operated at 12 centers for bariatric surgery participated in this randomized two-arm parallel study. During the operation, patients were randomized to closure of the mesenteric defects or non-closure. This study was a post-hoc analysis comparing HRQoL of the two groups before surgery, at 1 and 2 years after the operation. HRQoL was estimated using the short form 36 (SF-36-RAND) and the obesity problems (OP) scale.

RESULTS: Between May 1, 2010, and November 14, 2011, 2507 patients were included in the study and randomly assigned to mesenteric defect closure (n = 1259) or non-closure (n = 1248). In total, 1619 patients (64.6%) reported on their HRQoL at the 2-year follow-up. Mesenteric defect closure was associated with slightly higher rating of social functioning (87 ± 22.1 vs. 85 ± 24.2, p = 0.047) and role emotional (85 ± 31.5 vs. 82 ± 35.0, p = 0.027). No difference was seen on the OP scale (open defects 22 ± 24.8 vs. closed defects 20 ± 23.8, p = 0.125).

CONCLUSION: When comparing mesenteric defect closure with non-closure, there is no clinically relevant difference in HRQoL after laparoscopic gastric bypass surgery.

Place, publisher, year, edition, pages
Springer-Verlag New York, 2018. Vol. 28, no 1, 31-36 p.
Keyword [en]
Bariatric surgery, Laparoscopic gastric bypass, Small bowel obstruction, Internal hernia, Health-related quality-of-life, Randomized clinical trial
National Category
Gastroenterology and Hepatology Surgery
Identifiers
URN: urn:nbn:se:oru:diva-61780DOI: 10.1007/s11695-017-2798-zISI: 000418304500005PubMedID: 28676957Scopus ID: 2-s2.0-85021846101OAI: oai:DiVA.org:oru-61780DiVA: diva2:1152256
Note

Funding Agencies:

Örebro County Council, Örebro University  

Erling-Persson Family Foundation 

Available from: 2017-10-24 Created: 2017-10-24 Last updated: 2018-01-12Bibliographically approved

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Stenberg, ErikSzabo, Eva

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