oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Ten years transmission of the new variant of Chlamydia trachomatis in Sweden: prevalence of infections and associated complications
Section of Clinical Bacteriology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
WHO Collaborating Centre for Gonorrhoea and other STIs, Örebro University, Örebro, Sweden.
Department of Clinical Microbiology, Falu Lasarett, Falun, Sweden.
epartment of Clinical Microbiology, Sunderby Hospital, Luleå, Sweden.
Show others and affiliations
2018 (English)In: Sexually Transmitted Infections, ISSN 1368-4973, E-ISSN 1472-3263, Vol. 94, no 2, p. 100-104Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: In 2006, a new variant of Chlamydia trachomatis (nvCT) was discovered in Sweden. It has a deletion in the plasmid resulting in failed detection by the single target systems from Abbott and Roche used at that time, whereas the third system used, from Becton Dickinson (BD), detects nvCT. The proportion of nvCT was initially up to 65% in counties using Abbott/Roche systems. This study analysed the proportion of nvCT from 2007 to 2015 in four selected counties and its impact on chlamydia-associated complications.

METHODS: C. trachomatis-positive specimens collected from 2007 to 2015 were analysed by a specific PCR to identify nvCT cases. Genotyping was performed by multilocus sequence typing (MLST) and ompA sequencing. Ectopic pregnancy and pelvic inflammatory disease records were extracted from the national registers.

RESULTS: In total, 5101 C. trachomatis-positive samples were analysed. The nvCT proportion significantly decreased in the two counties using Roche systems, from 56% in 2007 to 6.5% in 2015 (p<0.001). In the two counties using BD systems, a decrease was also seen, from 19% in 2007 to 5.2% in 2015 (p<0.001). Fifteen nvCT cases from 2015 and 102 cases from 2006 to 2009 had identical MLST profiles. Counties using Roche/Abbott systems showed higher mean rates of ectopic pregnancy and pelvic inflammatory disease compared with counties using BD systems.

CONCLUSIONS: The nvCT proportion has decreased in all counties and converged to a low prevalence irrespective of previous rates. Genotyping showed that nvCT is clonal and genetically stable. Failing detection only marginally affected complication rates.

Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2018. Vol. 94, no 2, p. 100-104
Keywords [en]
chlamydia trachomatis, ectopic pregnancy, epidemiology, pelvic inflammatory disease, plasmid
National Category
Microbiology in the medical area Infectious Medicine
Identifiers
URN: urn:nbn:se:oru:diva-61756DOI: 10.1136/sextrans-2016-052992ISI: 000428207800007PubMedID: 28724744Scopus ID: 2-s2.0-85042848044OAI: oai:DiVA.org:oru-61756DiVA, id: diva2:1152561
Note

Funding Agencies:

Uppsala University Hospital  

Örebro County Council Research Committee  

Foundation for Medical Research at Örebro University Hospital, Sweden  

Available from: 2017-10-25 Created: 2017-10-25 Last updated: 2018-04-13Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Fredlund, HansUnemo, Magnus

Search in DiVA

By author/editor
Fredlund, HansUnemo, Magnus
In the same journal
Sexually Transmitted Infections
Microbiology in the medical areaInfectious Medicine

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 2 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf