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Lack of association between interleukin 28B polymorphism and vertical transmission of hepatitis C
Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Karolinska University Hospital, Stockholm, Sweden.
Örebro University, School of Medical Sciences. Department of Infectious Diseases, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.ORCID iD: 0000-0001-7248-0910
North-Western State Medical University of I.I.Mechnikov, Saint Petersburg, Russia.
Department of Laboratory Medicine, Division of Clinical Microbiology, Karolinska Institutet, Stockholm, Sweden.
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2017 (English)In: Journal of Pediatric Gastroenterology and Nutrition - JPGN, ISSN 0277-2116, E-ISSN 1536-4801, Vol. 65, no 6, p. 608-612Article in journal (Refereed) Published
Abstract [en]

OBJECTIVES: Single genetic nucleotide polymorphism (rs12979860) near the gene for Interleukin 28B (IL28B), is known to be of importance for frequency of spontaneous clearance and treatment outcome in interferon based therapies in patients with hepatitis C virus (HCV) infection. The aim of this study was to investigate if IL28B polymorphism in children and/or their mothers plays a role in vertical transmission of HCV (HCV-VT).

METHODS: Plasma samples from 59 infected women, 76 uninfected children born to infected mothers, and 47 children with known vertically transmitted HCV infection, were analysed for IL28B polymorphism and classified by the IL28B genotype (C/C, C/T and T/T) as well as by viral genotype.

RESULTS: The proportion of children with genotype C/C was the same in the vertically infected (36%, 17/47) and the exposed uninfected children (38%, 29/76). No difference was seen when stratifying for viral genotype. There was no association between mothers' IL28B genotype and the risk of vertical transmission.

CONCLUSION: Regardless of viral genotype we found no association between IL28B genotype and the risk of HCV-VT. The IL28B genotype CC, which has been shown to be favourable in other settings, was not protective of HCV-VT. Thus, other factors possibly associated with the risk of HCV-VT need to be explored.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2017. Vol. 65, no 6, p. 608-612
Keywords [en]
Hepatitis C, hepatitis C virus, interleukin 28B single genetic nucleotide polymorphism, mother-to-child-transmission, perinatal transmission
National Category
Pediatrics Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-61720DOI: 10.1097/MPG.0000000000001711ISI: 000419723400008PubMedID: 28820758Scopus ID: 2-s2.0-85033778792OAI: oai:DiVA.org:oru-61720DiVA, id: diva2:1155290
Funder
Swedish InstituteSwedish Research Council
Note

Funding Agencies:

ALF grants from Stockholm County Council  SLL-523300 

Örebro County Council  OLL-524441 

Stiftelsen Frimurare Barnhuset, Stockholm, Sweden  

Available from: 2017-11-07 Created: 2017-11-07 Last updated: 2018-09-03Bibliographically approved

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Duberg, Ann-Sofi

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