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Resilience to stress and risk of gastrointestinal infections
Örebro University, School of Medical Sciences. (Clinical Epidemiology and Biostatistics)
Örebro University, School of Medical Sciences. (Clinical Epidemiology and Biostatistics)ORCID iD: 0000-0002-2088-0530
(Clinical Epidemiology and Biostatistics)
Örebro University, School of Medical Sciences. Department of Gastroenterology, School of Medical Sciences, Örebro University, Örebro, Sweden.ORCID iD: 0000-0003-0122-7234
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2018 (English)In: European Journal of Public Health, ISSN 1101-1262, E-ISSN 1464-360X, Vol. 28, no 2, p. 364-369Article in journal (Refereed) Published
Abstract [en]

Background: Exposure to psychological stress can elicit a physiological response that may influence characteristics of the gastrointestinal mucosa, including increased intestinal permeability, in turn possibly increasing susceptibility to gastrointestinal infections. We investigated whether low stress resilience in adolescence is associated with an 'increased' risk of gastrointestinal infections in subsequent adulthood.

Methods: Data were provided by Swedish registers for a cohort of 237 577 men who underwent military conscription assessment in late adolescence (1969-76). As part of the assessment procedure, certified psychologists evaluated stress resilience through semi-structured interviews. The cohort was followed from conscription assessment until 31 December 2009 (up to age 57 years). Cox regression assessed the association of stress resilience with gastrointestinal infections (n = 5532), with adjustment for family background measures in childhood and characteristics in adolescence. Peptic ulcer disease (PUD) in adulthood was modelled as a time-dependent covariate.

Results: Compared with high stress resilience, lower stress resilience was associated with a 'reduced' risk of gastrointestinal infections after adjustment for family background in childhood, characteristics in adolescence and PUD in adulthood, with hazard ratios (and 95% confidence intervals) of 0.88 (0.81-0.97) and 0.83 (0.77-0.88) for low and moderate stress resilience, respectively.

Conclusion: Lower stress resilience in adolescence is associated with reduced risk of gastrointestinal infections in adulthood, rather than the hypothesized increased risk.

Place, publisher, year, edition, pages
Oxford, United Kingdom: Oxford University Press, 2018. Vol. 28, no 2, p. 364-369
National Category
Gastroenterology and Hepatology Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
URN: urn:nbn:se:oru:diva-62194DOI: 10.1093/eurpub/ckx179ISI: 000429036800032PubMedID: 29048469OAI: oai:DiVA.org:oru-62194DiVA, id: diva2:1155696
Note

Funding Agency:

Stiftelsen Olle Engkvist Byggmästare, UK Economic and Social Research Council (ESRC)  RES-596-28-0001  ES/JO19119/1

Available from: 2017-11-09 Created: 2017-11-09 Last updated: 2018-07-19Bibliographically approved

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Melinder, CarrenHiyoshi, AyakoHalfvarson, JonasFall, KatjaMontgomery, Scott

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