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Visualization of spirography-based objective measures in Parkinson's disease
School of Technology and Business Studies, Computer Engineering, Dalarna University, Falun, Sweden.ORCID iD: 0000-0002-2372-4226
Computer Science, University of California, Davis, USA.
Neuroscience, Neurology, Uppsala University, Uppsala, Sweden.
2014 (English)Conference paper, Oral presentation with published abstract (Other academic)
Abstract [en]

Objective: To investigate whether advanced visualizations of spirography-based objective measures are useful in differentiating motor complications among Parkinson’s disease (PD) patients.

Background: Sixty-five patients diagnosed with advanced PD have utilized a telemetry test battery, implemented on a touch screen handheld computer, in a telemedicine setting. On each test occasion, they were asked to perform repeated and time-stamped assessments of spiral drawing performance by tracing a pre-drawn Archimedes spiral. The test battery was also used by 10 healthy elderly (HE) subjects.

Methods: A web-based framework was developed to visualize the performance during spirography of both patients and HE subjects to a clinician (DN). The performance was depicted by animating the spiral drawings (Fig 1). In addition, the framework displayed two time series views for representing drawing speed (blue line) and displacement from the ideal trajectory (orange line). The views are coordinated and linked i.e. user interactions in one of the views will be reflected in other views. For instance, when the user points in one of the pixels in spiral view, the circle size of the underlying pixel increases and a vertical line appears in the time series views to depict the corresponding position. Fig 1 shows single randomly selected spirals per each subject group: A) a PD patient in Dyskinesia state, B) a HE subject, and C) a PD patient in Off state.

Results: The clinician recognized Dyskinesia symptoms as movements made with high speed, smooth/gradual spatial displacements, and a small amount of hesitation (Fig 1A). Similarly, Off symptoms were associated with low speed, sharp/abrupt spatial displacements, and a large amount of hesitation (Fig 1C). In contrast, the spiral drawn by a HE subject (Fig 1B) was associated with unchanging levels of kinematic features i.e. drawing speed, spatial displacements and hesitation over time.

Conclusions: Visualizing spirography-based objective measures enables identification of trends and patterns of motor dysfunctions at the patient’s individual level. Dynamic access of visualized motor tests may be useful during the evaluation of therapy-related complications such as under- and over-medications. This will assist during individualized optimization of therapies, enabling patients to spend more time in the On state with a minimum of Off and dyskinetic states.

Place, publisher, year, edition, pages
Wiley-Blackwell, 2014. Vol. 29 Suppl. 1, S187-S189 p., 505
Series
Movement Disorders, ISSN 0885-3185, E-ISSN 1531-8257
Keyword [en]
data visualization, objective measures, animation, time series, Parkinson's disease, spirography, motor dysfunctions
National Category
Information Systems, Social aspects Neurology
Identifiers
URN: urn:nbn:se:oru:diva-62599DOI: 10.1002/mds.25914ISI: 000337693401113OAI: oai:DiVA.org:oru-62599DiVA: diva2:1157496
Conference
18th International Congress of Parkinson's Disease and Movement Disorders, Stockholm, Sweden, June 8-12, 2014
Available from: 2017-11-16 Created: 2017-11-16 Last updated: 2017-11-21Bibliographically approved

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Memedi, Mevludin

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