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Mechanisms mediating skeletal muscle hypertrophy in older women following resistanceexercise combined to healthy diet
Örebro University, School of Health Sciences.
Örebro University, School of Health Sciences.ORCID iD: 0000-0002-8071-4745
School of Health and Medical Science, Örebro University, Sweden.
School of Health and Medical Science, Örebro University, Sweden.
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(English)Manuscript (preprint) (Other academic)
National Category
Sport and Fitness Sciences
Identifiers
URN: urn:nbn:se:oru:diva-62773OAI: oai:DiVA.org:oru-62773DiVA, id: diva2:1159581
Available from: 2017-11-23 Created: 2017-11-23 Last updated: 2017-11-23Bibliographically approved
In thesis
1. Skeletal Muscle Mass & Function in Older Women: Health-Enhancing Influences of Combined Resistance Exercise & Diet
Open this publication in new window or tab >>Skeletal Muscle Mass & Function in Older Women: Health-Enhancing Influences of Combined Resistance Exercise & Diet
2017 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Ageing is accompanied by a progressive decline in skeletal muscle mass and strength which may lead to impaired ability to perform activities of daily living in older adults. Although the exact cause of the gradual decline in muscle mass is unknown, identifying efficient strategies aiming to prevent age-related loss of muscle mass and strength is important in order to promote healthy ageing. The overall aim of this thesis was to explore the effects of resistance training alone or combined with a healthy diet on skeletal muscle mass and function of healthy recreationally active older women and to determine mechanisms by which elevated systemic inflammation may contribute to the age-related decline of muscle mass in older adults. The combination of resistance training and a healthy diet induced gains in leg lean mass as well as greater gains in dynamic explosive force than resistance training alone in healthy recreationally active older women. The observed gains in leg lean mass were accompanied by increases in the size of type IIA muscle fibres together with down-regulation in gene expression of a pro-inflammatory factor (IL-1β) and upregulation in gene expression of a regulator of cellular growth (mTOR) in skeletal muscle of older women. Additionally, reduced muscle protein synthesis and size of muscle cells may mediate the detrimental effects of elevated circulating markers of inflammation on muscle mass in older adults. In conclusion, the present thesis depicts mechanistic links between elevated systemic marker of inflammation and muscle mass and provides new information on the effects of combined resistance training and healthy diet on muscle mass and strength in a group of healthy recreationally active older women. This knowledge is instrumental for development of strategies aiming to prevent age-related loss of muscle mass and function.

Place, publisher, year, edition, pages
Örebro: Örebro University, 2017. p. 79
Series
Örebro Studies in Sport Sciences, ISSN 1654-7535 ; 26
Keywords
Healthy ageing, Chronic inflammation, C-reactive protein, Omega-3 fatty acids, Resistance training, Physical function
National Category
Sport and Fitness Sciences
Identifiers
urn:nbn:se:oru:diva-61234 (URN)978-91-7529-218-2 (ISBN)
Public defence
2017-12-12, Örebro universitet, Hörsal G, Gymnastikhuset, Fakultetsgatan 1, Örebro, 09:00 (Swedish)
Opponent
Supervisors
Available from: 2017-10-03 Created: 2017-10-03 Last updated: 2017-11-23Bibliographically approved

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Strandberg, EmeliePonsot, ElodieKadi, Fawzi

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