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Finegoldia magna Isolated from Orthopedic Joint Implant-Associated Infections
Örebro University, School of Medical Sciences. Department of Laboratory Medicine, Clinical Microbiology.ORCID iD: 0000-0001-5939-2932
School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden .
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Laboratory Medicine, Clinical Microbiology.
Department of Biomedicine, Aarhus University, Aarhus, Denmark .
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2017 (English)In: Journal of Clinical Microbiology, ISSN 0095-1137, E-ISSN 1098-660X, Vol. 55, no 11, 3283-3291 p.Article in journal (Refereed) Published
Abstract [en]

The anaerobic Gram-positive coccus Finegoldia magna is a rare cause of infections of bone and joints. The aim of this study was to describe the microbiological and clinical characteristics of orthopedic implant-associated infections caused by F. magna. We retrospectively analyzed samples consisting of anaerobic Gram-positive cocci and samples already identified as F. magna from patients with orthopedic infections. The isolates found were determined to the species level using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). The antibiotic susceptibility pattern was determined by Etest. Whole-genome sequencing (WGS) was performed. Clinical data were extracted from each patient's journal. In nine patients, orthopedic joint implant-associated infections were identified as being caused by F. magna. The isolates were susceptible to most of the antibiotics tested, with the exception of rifampin and moxifloxacin in a few cases. Five of the nine infections were monomicrobial. The most common antibiotic used to treat the infection was penicillin V, but five of the nine patients received a combination of antibiotics. Eight patients underwent surgical treatment, with extraction of the implant performed in seven cases and reimplantation in only two cases. The WGS showed a relatively small core genome, with 126,647 single nucleotide polymorphisms identified within the core genome. A phylogenomic analysis revealed that the isolates clustered into two distinct clades. Orthopedic implant-associated infections caused by F. magna are rare, but the bacteria are generally susceptible to antibiotics. Despite this, surgical treatment combined with long-term antibiotics is often necessary. The WGS analysis revealed a high heterogeneity and suggested the existence of at least two different Finegoldia species.

Place, publisher, year, edition, pages
American Society for Microbiology , 2017. Vol. 55, no 11, 3283-3291 p.
Keyword [en]
orthopedic implant-associated infections, prosthetic joint infections, Finegoldia magna, antibiotic susceptibility test, whole-genome sequencing
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:oru:diva-62812DOI: 10.1128/JCM.00866-17ISI: 000414356400019PubMedID: 28904182Scopus ID: 2-s2.0-85032443997OAI: oai:DiVA.org:oru-62812DiVA: diva2:1160157
Note

Funding Agencies:

Nyckelfonden at Örebro University Hospital  OLL-595951 

Danish Medical Research council  DFF-1331-00241 

Available from: 2017-11-24 Created: 2017-11-24 Last updated: 2018-01-13Bibliographically approved

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Söderquist, BoHellmark, Bengt

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