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Finegoldia magna Isolated from Orthopedic Joint Implant-Associated Infections
Örebro University, School of Medical Sciences.ORCID iD: 0000-0001-5939-2932
Department of Laboratory Medicine, Clinical Microbiology, Örebro University Hospital, Örebro, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Laboratory Medicine.
Department of Biomedicine, Aarhus University, Aarhus, Denmark.
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2017 (English)In: Journal of Clinical Microbiology, ISSN 0095-1137, E-ISSN 1098-660X, Vol. 55, no 11, p. 3283-3291Article in journal (Refereed) Published
Abstract [en]

The anaerobic Gram-positive coccus Finegoldia magna is a rare cause of infections of bone and joints. The aim of this study was to describe the microbiological and clinical characteristics of orthopedic implant-associated infections caused by F. magna We retrospectively analyzed samples consisting of anaerobic Gram-positive cocci and samples already identified as F. magna from patients with orthopedic infections. The isolates found were determined to the species level using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). The antibiotic susceptibility pattern was determined by Etest. Whole-genome sequencing (WGS) was performed. Clinical data were extracted from each patient's journal. In nine patients, orthopedic joint implant-associated infections were identified as being caused by F. magna The isolates were susceptible to most of the antibiotics tested, with the exception of rifampin and moxifloxacin in a few cases. Five of the nine infections were monomicrobial. The most common antibiotic used to treat the infection was penicillin V, but five of the nine patients received a combination of antibiotics. Eight patients underwent surgical treatment, with extraction of the implant performed in seven cases and reimplantation in only two cases. The WGS showed a relatively small core genome, with 126,647 single nucleotide polymorphisms identified within the core genome. A phylogenomic analysis revealed that the isolates clustered into two distinct clades. Orthopedic implant-associated infections caused by F. magna are rare, but the bacteria are generally susceptible to antibiotics. Despite this, surgical treatment combined with long-term antibiotics is often necessary. The WGS analysis revealed a high heterogeneity and suggested the existence of at least two different Finegoldia species.

Place, publisher, year, edition, pages
American Society for Microbiology , 2017. Vol. 55, no 11, p. 3283-3291
Keyword [en]
Finegoldia magna, antibiotic susceptibility test, orthopedic implant-associated infections, prosthetic joint infections, whole-genome sequencing
National Category
Infectious Medicine
Identifiers
URN: urn:nbn:se:oru:diva-62478DOI: 10.1128/JCM.00866-17ISI: 000414356400019PubMedID: 28904182Scopus ID: 2-s2.0-85032443997OAI: oai:DiVA.org:oru-62478DiVA, id: diva2:1162247
Note

Funding agencies:

Nyckelfonden at Orebro University Hospital OLL-595951 

Danish Medical Research council DFF-1331-00241 

Available from: 2017-12-04 Created: 2017-12-04 Last updated: 2018-01-03Bibliographically approved

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Söderquist, BoHellmark, Bengt

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