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Levels of beta-trace protein in optic disc pit with macular detachment
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Ophthalmology.
Department of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, Sweden; Faculty of Medicine and Health Department of Biomedicine, Örebro University, Örebro, Sweden.
Örebro University, School of Medical Sciences. Department of Ophthalmology.
2017 (English)In: Acta Ophthalmologica, ISSN 1755-375X, E-ISSN 1755-3768, Vol. 95, no 8, p. 815-819Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: To report beta-trace protein (βTP) levels in the subretinal fluid (SRF) of four patients with a macular detachment associated with optic disc pit (ODP).

METHODS: Four patients with a serous retinal detachment involving the macula was operated by pars plana vitrectomy (PPV) with C2 F6 gas tamponade and peeling of internal limiting membrane (ILM). Patients with a follow-up period exceeding one year postoperatively were included in the study. The SRF was drained using a fine cannula without laser photocoagulation, and the samples were analysed using particle-enhancing nephelometry. The levels of βTP were compared to 20 routine cerebrospinal fluid (CSF) samples.

RESULTS: In four of the five samples from SRF had relatively low βTP levels, with a mean concentration of 6.6 mg/l (range 2.0 to 23.1 mg/l) compared to 16.0 mg/l (range 6.3-26.8 mg/l) in CSF. The only SRF sample within the range corresponding to normal CSF was the first sample from patient 4, and the analysis of the renewed aspirate during the second operation was 2.8 mg/l. Postoperatively, the regression of SRF was slow, but regression of SRF in the foveal region took place in all cases; however, visual acuity (VA) was improved in only half of the patients.

CONCLUSION: The results from the analysed SRF regarding βTP concentration in these patients indicate that the SRF in ODP is not identical to CSF, as the concentrations of βTP differ.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2017. Vol. 95, no 8, p. 815-819
Keywords [en]
beta trace, beta-trace protein, optic disc pit, β-trace protein
National Category
Ophthalmology
Identifiers
URN: urn:nbn:se:oru:diva-62465DOI: 10.1111/aos.13527ISI: 000417645900036PubMedID: 28926186Scopus ID: 2-s2.0-85030124493OAI: oai:DiVA.org:oru-62465DiVA, id: diva2:1162340
Available from: 2017-12-04 Created: 2017-12-04 Last updated: 2017-12-21Bibliographically approved

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Makdoumi, KarimNilsson, Torbjörn K.Crafoord, Sven

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