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Early Electroencephalography Suppression and Postnatal Morbidities Correlate with Cerebral Volume at Term-Equivalent Age in Very Preterm Infants
Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Women's and Children's Health, Uppsala University, Uppsala, Sweden.
Department of Pediatrics and Clinical Sciences, Skane University Hospital, Lund University, Lund, Sweden.
Department of Pediatrics and Clinical Sciences, Skane University Hospital, Lund University, Lund, Sweden.
Department of Pediatrics and Clinical Sciences, Skane University Hospital, Lund University, Lund, Sweden.
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2018 (English)In: Neonatology, ISSN 1661-7800, E-ISSN 1661-7819, Vol. 113, no 1, p. 15-20Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Early brain activity is associated with long-term outcome. Establishing a relation also with postnatal brain growth may increase our understanding of early life influences on preterm brain development.

OBJECTIVES: The aim of this study was to investigate whether early electroencephalography (EEG) activity in infants born very preterm is associated with brain volumes at term, and whether postnatal morbidity affects this association.

METHODS: Very preterm infants (n = 38) with a median gestational age (GA) of 25.6 weeks had early recordings of single-channel EEG. The percentage of suppressed EEG, i.e., interburst intervals (IBI%) between 24 and 72 h of age, was analyzed in relation to brain volumes on magnetic resonance imaging performed at term-equivalent age, taking into account neonatal morbidities.

RESULTS: Early electrocortical depression and a higher IBI% were associated with increased cerebrospinal fluid volume (CSFV) and lower total brain volume relative to intracranial volume, also after adjustment for GA, postnatal morbidities, morphine administration, and postnatal head growth. Overall, an increase in IBI% to 1 SD from the mean corresponded with an increase in CSFV to +0.7 SD and a decrease in brain volume to -0.7 SD. The presence of 2 or more postnatal morbidities were associated with around 10% lower brain volumes.

CONCLUSIONS: More suppressed early EEG activity of very preterm infants is associated with lower brain volume and increased CSFV at term age, also when adjusting for postnatal morbidities. The findings indicate the importance of pre- and early postpartal determinants of postnatal brain growth, possibly also including activity-dependent mechanisms for brain growth.

Place, publisher, year, edition, pages
S. Karger, 2018. Vol. 113, no 1, p. 15-20
Keywords [en]
Brain development, Cerebrospinal fluid, Electroencephalography, Magnetic resonance imaging, Preterm
National Category
Pediatrics
Identifiers
URN: urn:nbn:se:oru:diva-62462DOI: 10.1159/000479423ISI: 000418304700003PubMedID: 28934743Scopus ID: 2-s2.0-85029758648OAI: oai:DiVA.org:oru-62462DiVA, id: diva2:1162449
Funder
Swedish Research Council, 0037 14940 0084
Note

Funding Agencies:

Linnea and Josef Carlsson Foundation, Region Skåne, Sweden  

County Council of Värmland

Örebro University  

Uppsala University, Sweden 

Available from: 2017-12-04 Created: 2017-12-04 Last updated: 2018-01-12Bibliographically approved

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Wikström, Sverre

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