oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Surgical treatment in childhood-onset inflammatory bowel disease: A nationwide register-based study of 4695 incident patients in Sweden 2002-2014
Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Center for Digestive Disease, Karolinska University Hospital, Stockholm, Sweden.
Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden; Department of Surgery, County Council of Östergötland, Linköping, Sweden.
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
Show others and affiliations
2018 (English)In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no 2, p. 157-166Article in journal (Refereed) Published
Abstract [en]

Background and Aims: The incidence of childhood-onset (<18 years) inflammatory bowel disease is increasing worldwide, and some studies suggest that it represents a more severe disease phenotype. Few nationwide, population-based studies have evaluated the surgical burden in patients with childhood-onset IBD, and whether the improved medical treatment has influenced the need for gastrointestinal surgery. The aim was to examine whether the surgical treatment at any age of patients with childhood-onset IBD has changed over time.

Methods: In a nationwide cohort study we identified 4,695 children (<18 years) diagnosed with incident IBD in 2002-2014 through the Swedish Patient Register (ulcerative colitis: n=2,295; Crohn's disease: n=2,174; inflammatory bowel disease-unclassified: n=226). Abdominal (intestinal resections and colectomies) and perianal surgery were identified through the Swedish Patient Register. The cumulative incidences of surgeries were calculated using the Kaplan Meier method.

Results: In the cohort, 44% were females and 56% males. The median age at inflammatory bowel disease diagnosis was 15 years and the maximum age at end of follow-up was 31 years. The three-year cumulative incidence of intestinal surgery was 5% in patients with ulcerative colitis and 7% in patients with Crohn's disease, and lower in children <6 years at inflammatory bowel disease diagnosis (3%) than in those aged 15-17 years at diagnosis (7%). Calendar period of inflammatory bowel disease diagnosis was not associated with risk of surgery.

Conclusion: Over the last 13 years, the risk of surgery in childhood-onset inflammatory bowel disease has remained unchanged.

Place, publisher, year, edition, pages
Oxford University Press, 2018. Vol. 12, no 2, p. 157-166
Keywords [en]
Children; inflammatory bowel disease; surgery
National Category
Gastroenterology and Hepatology
Identifiers
URN: urn:nbn:se:oru:diva-62421DOI: 10.1093/ecco-jcc/jjx132ISI: 000423703000004PubMedID: 29029152Scopus ID: 2-s2.0-85041295862OAI: oai:DiVA.org:oru-62421DiVA, id: diva2:1164405
Funder
Swedish Society of MedicineSwedish Research Council
Note

Funding Agencies:

Bengt Ihre research fellowship

Karolinska Institutet Foundations  

Stockholm County Council  

Jane and Dan Olsson Foundation  

Kempe Carlgrenska Foundation  

Mjölkdroppen Foundation  

Stockholm County Council [ALF project] 

Available from: 2017-12-11 Created: 2017-12-11 Last updated: 2018-02-12Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Ludvigsson, Jonas F.

Search in DiVA

By author/editor
Ludvigsson, Jonas F.
By organisation
School of Medical SciencesÖrebro University Hospital
In the same journal
Journal of Crohn's & Colitis
Gastroenterology and Hepatology

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 45 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf