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RhoB controls the Rab11-mediated recycling and surface reappearance of LFA-1 in migrating T lymphocytes
Department of Experimental Medical Science, Lund University, Lund, Sweden.
Department of Experimental Medical Science, Lund University, Lund, Sweden.
Department of Experimental Medical Science, Lund University, Lund, Sweden.
Department of Solid State Physics, Lund University, Lund, Sweden.
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2017 (English)In: Science Signaling, ISSN 1945-0877, E-ISSN 1937-9145, Vol. 10, no 509, article id eaai8629Article in journal (Refereed) Published
Abstract [en]

The regulation of cell adhesion and motility is complex and requires the intracellular trafficking of integrins to and from sites of cell adhesion, especially in fast-moving cells such as leukocytes. The Rab family of guanosine triphosphatases (GTPases) is essential for vesicle transport, and vesicles mediate intracellular integrin trafficking. We showed that RhoB regulates the vesicular transport of the integrin LFA-1 along the microtubule network in migrating T lymphocytes. Impairment in RhoB function resulted in the accumulation of both LFA-1 and the recycling endosomal marker Rab11 at the rear of migrating T lymphocytes and decreased the association between these molecules. T lymphocytes lacking functional RhoB exhibited impaired recycling and subsequently decreased surface amounts of LFA-1, leading to reduced T cell adhesion and migration mediated by the cell adhesion molecule ICAM-1 (intercellular adhesion molecule-1). We propose that vesicle-associated RhoB is a regulator of the Rab11-mediated recycling of LFA-1 to the cell surface, an event that is necessary for T lymphocyte motility.

Place, publisher, year, edition, pages
Washington, DC, USA: American Association for the Advancement of Science (A A A S) , 2017. Vol. 10, no 509, article id eaai8629
National Category
Biochemistry and Molecular Biology
Identifiers
URN: urn:nbn:se:oru:diva-63406DOI: 10.1126/scisignal.aai8629ISI: 000417850600001PubMedID: 29233918Scopus ID: 2-s2.0-85038418417OAI: oai:DiVA.org:oru-63406DiVA, id: diva2:1167555
Funder
Swedish Research Council, K2010-80P-21592-01-4 K2010-80X-215917-01-4The Royal Swedish Academy of Sciences
Note

Funding Agencies:

Foundation Olle Engquist Byggmästare  

IngaBritt & Arne Lundberg Research Foundation  

Royal Physiographic Society of Lund  

Åke Wiberg  

Jeanssons Foundation  

Kocks Foundation  

Per-Eric and Ulla Schybergs Foundation  

Gyllenstiernska Krapperup Foundation  

Gustav V 80 Jubilee Fund  

Österlund Foundation  

Nanna Svartz award  

Crafoord award  

Anna-Greta Crafoord postdoctoral fellowship 

Available from: 2017-12-19 Created: 2017-12-19 Last updated: 2018-01-04Bibliographically approved

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