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Midlife metabolic factors and prostate cancer risk in later life
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA.
Centre for Public Health Sciences, University of Iceland, Reykjavik, Iceland.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA; Centre for Public Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston MA, USA; Centre for Public Health Sciences, University of Iceland, Reykjavik, Iceland; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
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2018 (English)In: International Journal of Cancer, ISSN 0020-7136, E-ISSN 1097-0215, Vol. 142, no 6, p. 1166-1173Article in journal (Refereed) Published
Abstract [en]

Metabolic syndrome is associated with several cancers, but evidence for aggressive prostate cancer is sparse. We prospectively investigated the influence of metabolic syndrome and its components on risk of total prostate cancer and measures of aggressive disease in a cohort of Icelandic men. Men in the Reykjavik Study (n = 9,097, enrolled 1967-1987) were followed for incident (n = 1,084 total; n = 378 advanced; n = 148 high-grade) and fatal (n = 340) prostate cancer until 2014. Cox regression was used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for (1) measured metabolic factors at cohort entry (body mass index (BMI), blood pressure, triglycerides, fasting blood glucose) and (2) a metabolic syndrome score (range 0-4) combining the risk factors: BMI ≥30 kg/m2 ; systolic blood pressure (SBP) ≥130 or diastolic blood pressure (DBP) ≥85 mm Hg or taking antihypertensives; triglycerides ≥150 mg/dl; fasting blood glucose ≥100 mg/dl or self-reported type 2 diabetes. Hypertension and type 2 diabetes were associated with a higher risk of total, advanced, high-grade, and fatal prostate cancer, independent of BMI. Neither BMI nor triglycerides were associated with prostate cancer risk. Higher metabolic syndrome score (3-4 vs 0) was associated with a higher risk of fatal prostate cancer (HR 1.55; 95% CI: 0.89, 2.69; p trend = 0.08), although this finding was not statistically significant. Our findings suggest a positive association between midlife hypertension and diabetes and risk of total and aggressive prostate cancer. Further, metabolic syndrome as a combination of factors was associated with an increased risk of fatal prostate cancer.

Place, publisher, year, edition, pages
Hoboken, USA: John Wiley & Sons, 2018. Vol. 142, no 6, p. 1166-1173
Keywords [en]
Prostate cancer, metabolic syndrome, BMI, hypertension, triglycerides, fasting blood glucose, diabetes
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-63449DOI: 10.1002/ijc.31142ISI: 000422753700009PubMedID: 29114858Scopus ID: 2-s2.0-85034034113OAI: oai:DiVA.org:oru-63449DiVA, id: diva2:1167872
Note

Funding Agencies:

National Cancer Institute at the National Institutes of Health  T32 CA09001 

American Institute for Cancer Research  

Nordic HealthWhole Grain Food (HELGA)  

Dana-Farber/Harvard Cancer Center SPORE in Prostate Cancer  P50 CA090381 

Available from: 2017-12-19 Created: 2017-12-19 Last updated: 2018-08-16Bibliographically approved

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Fall, Katja

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