The gut microbiota modulates host energy and lipid metabolism in miceShow others and affiliations
2010 (English)In: Journal of Lipid Research, ISSN 0022-2275, E-ISSN 1539-7262, Vol. 51, no 5, p. 1101-1112Article in journal (Refereed) Published
Abstract [en]
The gut microbiota has recently been identified as an environmental factor that may promote metabolic diseases. To investigate the effect of gut microbiota on host energy and lipid metabolism, we compared the serum metabolome and the lipidomes of serum, adipose tissue, and liver of conventionally raised (CONV-R) and germ-free mice. The serum metabolome of CONV-R mice was characterized by increased levels of energy metabolites, e.g., pyruvic acid, citric acid, fumaric acid, and malic acid, while levels of cholesterol and fatty acids were reduced. We also showed that the microbiota modified a number of lipid species in the serum, adipose tissue, and liver, with its greatest effect on triglyceride and phosphatidylcholine species. Triglyceride levels were lower in serum but higher in adipose tissue and liver of CONV-R mice, consistent with increased lipid clearance. Our findings show that the gut microbiota affects both host energy and lipid metabolism and highlights its role in the development of metabolic diseases.
Place, publisher, year, edition, pages
2010. Vol. 51, no 5, p. 1101-1112
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:oru:diva-63624DOI: 10.1194/jlr.M002774ISI: 000276633100026PubMedID: 20040631Scopus ID: 2-s2.0-77951087292OAI: oai:DiVA.org:oru-63624DiVA, id: diva2:1169190
Funder
Swedish Foundation for Strategic Research EU, FP7, Seventh Framework Programme, FP7-KBBE-222639Wenner-Gren FoundationsÅke Wiberg FoundationMagnus Bergvall Foundation
Note
Human Frontier of Science Program RGY64/2008
Swedish Research Council K2007-65X-20421-01-04
Lars Hierta's Foundation
Nanna Svartz Foundation
Fredrik and Ingrid Thurings Foundations
Swedish Nutrition Foundation
Vastra Gotalandsregionen
2017-12-222017-12-222018-01-22Bibliographically approved