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The gut microbiota modulates host energy and lipid metabolism in mice
VTT Technical Research Centre of Finland, Espoo, Finland.
Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.
Sahlgrenska Center for Cardiovascular and Metabolic Research/Wallenberg Laboratory, University of Gothenburg, Gothenburg, Sweden; Department of Molecular and Clinical Medicine, University of Gothenburg, Gothenburg, Sweden.
VTT Technical Research Centre of Finland, Espoo, Finland.
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2010 (English)In: Journal of Lipid Research, ISSN 0022-2275, E-ISSN 1539-7262, Vol. 51, no 5, 1101-1112 p.Article in journal (Refereed) Published
Abstract [en]

The gut microbiota has recently been identified as an environmental factor that may promote metabolic diseases. To investigate the effect of gut microbiota on host energy and lipid metabolism, we compared the serum metabolome and the lipidomes of serum, adipose tissue, and liver of conventionally raised (CONV-R) and germ-free mice. The serum metabolome of CONV-R mice was characterized by increased levels of energy metabolites, e.g., pyruvic acid, citric acid, fumaric acid, and malic acid, while levels of cholesterol and fatty acids were reduced. We also showed that the microbiota modified a number of lipid species in the serum, adipose tissue, and liver, with its greatest effect on triglyceride and phosphatidylcholine species. Triglyceride levels were lower in serum but higher in adipose tissue and liver of CONV-R mice, consistent with increased lipid clearance. Our findings show that the gut microbiota affects both host energy and lipid metabolism and highlights its role in the development of metabolic diseases.

Place, publisher, year, edition, pages
2010. Vol. 51, no 5, 1101-1112 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:oru:diva-63624DOI: 10.1194/jlr.M002774ISI: 000276633100026PubMedID: 20040631Scopus ID: 2-s2.0-77951087292OAI: oai:DiVA.org:oru-63624DiVA: diva2:1169190
Funder
Swedish Foundation for Strategic Research EU, FP7, Seventh Framework Programme, FP7-KBBE-222639Wenner-Gren FoundationsÅke Wiberg FoundationMagnus Bergvall Foundation
Note

Human Frontier of Science Program RGY64/2008 

Swedish Research Council K2007-65X-20421-01-04   

Lars Hierta's Foundation  

Nanna Svartz Foundation  

Fredrik and Ingrid Thurings Foundations  

Swedish Nutrition Foundation  

Vastra Gotalandsregionen 

Available from: 2017-12-22 Created: 2017-12-22 Last updated: 2018-01-22Bibliographically approved

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Oresic, Matej

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