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Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming.
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2010 (English)In: Immunity, ISSN 1074-7613, E-ISSN 1097-4180, Vol. 32, no 6, 852-62 p.Article in journal (Refereed) Published
Abstract [en]

Dissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th2 cells is important for understanding the pathogenesis of immune-mediated diseases, such as asthma and allergy. Because the STAT6 transcription factor is an upstream mediator required for interleukin-4 (IL-4)-induced Th2 cell differentiation, its targets include genes important for this process. Using primary human CD4(+) T cells, and by blocking STAT6 with RNAi, we identified a number of direct and indirect targets of STAT6 with ChIP sequencing. The integration of these data sets with detailed kinetics of IL-4-driven transcriptional changes showed that STAT6 was predominantly needed for the activation of transcription leading to the Th2 cell phenotype. This integrated genome-wide data on IL-4- and STAT6-mediated transcription provide a unique resource for studies on Th cell differentiation and, in particular, for designing interventions of human Th2 cell responses.

Place, publisher, year, edition, pages
2010. Vol. 32, no 6, 852-62 p.
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Medical and Health Sciences
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URN: urn:nbn:se:oru:diva-63632DOI: 10.1016/j.immuni.2010.06.011PubMedID: 20620947OAI: oai:DiVA.org:oru-63632DiVA: diva2:1169198
Available from: 2017-12-22 Created: 2017-12-22 Last updated: 2017-12-22

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