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Genome-wide profiling of interleukin-4 and STAT6 transcription factor regulation of human Th2 cell programming
Biomathematics Research Group, Department of Mathematics, University of Turku, Turku, Finland; Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland.
Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland.
Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland; Turku Graduate School of Biomedical Sciences, Turku, Finland.
Turku Centre for Biotechnology, University of Turku and Åbo Akademi, Turku, Finland.
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2010 (English)In: Immunity, ISSN 1074-7613, E-ISSN 1097-4180, Vol. 32, no 6, p. 852-862Article in journal (Refereed) Published
Abstract [en]

Dissecting the molecular mechanisms by which T helper (Th) cells differentiate to effector Th2 cells is important for understanding the pathogenesis of immune-mediated diseases, such as asthma and allergy. Because the STAT6 transcription factor is an upstream mediator required for interleukin-4 (IL-4)-induced Th2 cell differentiation, its targets include genes important for this process. Using primary human CD4(+) T cells, and by blocking STAT6 with RNAi, we identified a number of direct and indirect targets of STAT6 with ChIP sequencing. The integration of these data sets with detailed kinetics of IL-4-driven transcriptional changes showed that STAT6 was predominantly needed for the activation of transcription leading to the Th2 cell phenotype. This integrated genome-wide data on IL-4- and STAT6-mediated transcription provide a unique resource for studies on Th cell differentiation and, in particular, for designing interventions of human Th2 cell responses.

Place, publisher, year, edition, pages
Cell Press , 2010. Vol. 32, no 6, p. 852-862
National Category
Cell Biology
Identifiers
URN: urn:nbn:se:oru:diva-63632DOI: 10.1016/j.immuni.2010.06.011ISI: 000279365800015PubMedID: 20620947Scopus ID: 2-s2.0-77953881949OAI: oai:DiVA.org:oru-63632DiVA, id: diva2:1169198
Funder
Academy of Finland, 77773 203725 207490 116639 115939 123864 126063 127575 120569
Note

Funding agencies:

European Commission EC-FP7-SYBILLA-201106 EC-FP7-NANOMMUNE-214281 EC-FP7-DIABIMMUNE-202063 

CIMO/Sitra

Sigrid Juselius Foundation

Department of Biotechnology, Government of India

Turku University Hospital

Note:  The Turku Centre for Biotechnology is a joint department of the Turku University and the Åbo Akademi University

Available from: 2017-12-22 Created: 2017-12-22 Last updated: 2018-05-02Bibliographically approved

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