oru.sePublikationer
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
MPEA--metabolite pathway enrichment analysis.
Örebro University, School of Medical Sciences.
2011 (English)In: Bioinformatics, ISSN 1367-4803, E-ISSN 1367-4811, Vol. 27, no 13, 1878-9 p.Article in journal (Refereed) Published
Abstract [en]

UNLABELLED: We present metabolite pathway enrichment analysis (MPEA) for the visualization and biological interpretation of metabolite data at the system level. Our tool follows the concept of gene set enrichment analysis (GSEA) and tests whether metabolites involved in some predefined pathway occur towards the top (or bottom) of a ranked query compound list. In particular, MPEA is designed to handle many-to-many relationships that may occur between the query compounds and metabolite annotations. For a demonstration, we analysed metabolite profiles of 14 twin pairs with differing body weights. MPEA found significant pathways from data that had no significant individual query compounds, its results were congruent with those discovered from transcriptomics data and it detected more pathways than the competing metabolic pathway method did.

AVAILABILITY: The web server and source code of MPEA are available at http://ekhidna.biocenter.helsinki.fi/poxo/mpea/.

Place, publisher, year, edition, pages
2011. Vol. 27, no 13, 1878-9 p.
National Category
Medical and Health Sciences
Identifiers
URN: urn:nbn:se:oru:diva-63645DOI: 10.1093/bioinformatics/btr278PubMedID: 21551139OAI: oai:DiVA.org:oru-63645DiVA: diva2:1169210
Available from: 2017-12-22 Created: 2017-12-22 Last updated: 2017-12-22

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed
By organisation
School of Medical Sciences
In the same journal
Bioinformatics
Medical and Health Sciences

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf