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Effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile and inflammation markers in metabolic syndrome: a randomized study (SYSDIET)
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Research Unit, Kuopio University Hospital, Kuopio, Finland.
Department of Medicine and Endocrinology MEA, Aarhus University Hospital, Aarhus, Denmark.
Institute of Clinical Medicine, Department of Internal Medicine, University of Oulu, Oulu, Finland.
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland.
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2013 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 274, no 1, p. 52-66Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Different healthy food patterns may modify cardiometabolic risk. We investigated the effects of an isocaloric healthy Nordic diet on insulin sensitivity, lipid profile, blood pressure and inflammatory markers in people with metabolic syndrome.

METHODS: We conducted a randomized dietary study lasting for 18-24 weeks in individuals with features of metabolic syndrome (mean age 55 years, BMI 31.6 kg m(-2) , 67% women). Altogether 309 individuals were screened, 200 started the intervention after 4-week run-in period, and 96 (proportion of dropouts 7.9%) and 70 individuals (dropouts 27%) completed the study, in the Healthy diet and Control diet groups, respectively. Healthy diet included whole-grain products, berries, fruits and vegetables, rapeseed oil, three fish meals per week and low-fat dairy products. An average Nordic diet served as a Control diet. Compliance was monitored by repeated 4-day food diaries and fatty acid composition of serum phospholipids.

RESULTS: Body weight remained stable, and no significant changes were observed in insulin sensitivity or blood pressure. Significant changes between the groups were found in non-HDL cholesterol (-0.18, mmol L(-1) 95% CI -0.35; -0.01, P = 0.04), LDL to HDL cholesterol (-0.15, -0.28; -0.00, P = 0.046) and apolipoprotein B to apolipoprotein A1 ratios (-0.04, -0.07; -0.00, P = 0.025) favouring the Healthy diet. IL-1 Ra increased during the Control diet (difference -84, -133; -37 ng L(-1) , P = 0.00053). Intakes of saturated fats (E%, beta estimate 4.28, 0.02; 8.53, P = 0.049) and magnesium (mg, -0.23, -0.41; -0.05, P = 0.012) were associated with IL-1 Ra.

CONCLUSIONS: Healthy Nordic diet improved lipid profile and had a beneficial effect on low-grade inflammation.

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2013. Vol. 274, no 1, p. 52-66
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:oru:diva-63676DOI: 10.1111/joim.12044ISI: 000320279000004PubMedID: 23398528Scopus ID: 2-s2.0-84879123209OAI: oai:DiVA.org:oru-63676DiVA, id: diva2:1169241
Funder
Swedish Heart Lung FoundationSwedish Diabetes Association
Note

Funding agencieas:

NordForsk

Academy of Finland

Finnish Diabetes Research Foundation

Finnish Foundation for Cardiovascular Research

Sigfrid Juselius Foundation

Kuopio University Hospital (Finland)

Druvan Foundation

ESPEN

Skane County Council Research and Development Foundationl

Foundation Cerealia (Sweden)

Danish Obesity Research Centre (DanORC)

Danish Council for Strategic Research (Dairy-Health, BioFunCarb) (Denmark)

Agricultural Productivity Fund

University of Iceland (Iceland)

Available from: 2017-12-22 Created: 2017-12-22 Last updated: 2018-05-29Bibliographically approved

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