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Characterization of cerebrospinal fluid by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry
VTT Technical Research Centre of Finland, Helsiniki, Finland.
VTT Technical Research Centre of Finland, Helsiniki, Finland.
VTT Technical Research Centre of Finland, Helsiniki, Finland.
Örebro University, School of Medical Sciences. VTT Technical Research Centre of Finland, Helsiniki, Finland.ORCID iD: 0000-0002-2856-9165
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2013 (English)In: Journal of Chromatography A, ISSN 0021-9673, E-ISSN 1873-3778, Vol. 1293, p. 142-149, article id S0021-9673(13)00567-0Article in journal (Refereed) Published
Abstract [en]

Comprehensive two-dimensional gas chromatography-time-of-flight mass spectrometry (GC×GC-TOFMS) was applied in the quantification and identification of organic compounds in patient-matched human cerebrospinal fluid (CSF) and serum samples. Concentrations of 21 amino and hydroxyl acids varied from 0.04 to 77ng/μl in CSF and from 0.1 to 84ng/μl in serum. In total, 91 metabolites out of over 1200 detected were identified based on mass spectra and retention indices. The other metabolites were identified at the functional group level. The main metabolites detected in CSF were sugar and amino acid derivatives. The CSF and serum had clearly distinct metabolic profiles, with larger biological variation in the serum than in CSF. The GC×GC-TOFMS allowed detection and identification of several metabolites that have not been previously detected in CSF.

Place, publisher, year, edition, pages
2013. Vol. 1293, p. 142-149, article id S0021-9673(13)00567-0
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:oru:diva-63681DOI: 10.1016/j.chroma.2013.04.005ISI: 000319482200017PubMedID: 23642768Scopus ID: 2-s2.0-84877622341OAI: oai:DiVA.org:oru-63681DiVA, id: diva2:1169247
Funder
EU, FP7, Seventh Framework Programme, TBI-Care (FP7-ICT-270259) ETHERPATHS (FP7-KBBE-222639) TORNADO FP7-KBBE-222720)Academy of Finland, 253085Available from: 2017-12-22 Created: 2017-12-22 Last updated: 2019-03-04Bibliographically approved

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Oresic, MatejHyötyläinen, Tuulia

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