oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Decreased cord-blood phospholipids in young age-at-onset type 1 diabetes
Department of Clinical Sciences, Lund University Clinical Research Centre, Skåne University Hospital, Malmö, Sweden.
VTT Technical Research Centre of Finland, Espoo, Finland.
Department of Clinical Sciences, Lund University Clinical Research Centre, Skåne University Hospital, Malmö, Sweden.
Örebro University, School of Science and Technology. VTT Technical Research Centre of Finland, Espoo, Finland.
Show others and affiliations
2013 (English)In: Diabetes, ISSN 0012-1797, E-ISSN 1939-327X, Vol. 62, no 11, p. 3951-3956Article in journal (Refereed) Published
Abstract [en]

Children developing type 1 diabetes may have risk markers already in their umbilical cord blood. It is hypothesized that the risk for type 1 diabetes at an early age may be increased by a pathogenic pregnancy and be reflected in altered cord-blood composition. This study used metabolomics to test if the cord-blood lipidome was affected in children diagnosed with type 1 diabetes before 8 years of age. The present case-control study of 76 index children diagnosed with type 1 diabetes before 8 years of age and 76 healthy control subjects matched for HLA risk, sex, and date of birth, as well as the mother's age and gestational age, revealed that cord-blood phosphatidylcholines and phosphatidylethanolamines were significantly decreased in children diagnosed with type 1 diabetes before 4 years of age. Reduced levels of triglycerides correlated to gestational age in index and control children and to age at diagnosis only in the index children. Finally, gestational infection during the first trimester was associated with lower cord-blood total lysophosphatidylcholines in index and control children. In conclusion, metabolomics of umbilical cord blood may identify children at increased risk for type 1 diabetes. Low phospholipid levels at birth may represent key mediators of the immune system and contribute to early induction of islet autoimmunity.

Place, publisher, year, edition, pages
2013. Vol. 62, no 11, p. 3951-3956
National Category
Endocrinology and Diabetes Immunology in the medical area Pediatrics
Identifiers
URN: urn:nbn:se:oru:diva-63686DOI: 10.2337/db13-0215ISI: 000326290700039PubMedID: 23929934Scopus ID: 2-s2.0-84890747164OAI: oai:DiVA.org:oru-63686DiVA, id: diva2:1169252
Funder
Swedish Research CouncilEU, FP7, Seventh Framework Programme, DIAPREPP 202013Swedish Diabetes AssociationKnut and Alice Wallenberg Foundation
Note

Funding agencies:

Lund University Diabetes Centre

Academy of Finland

Centre of Excellence in Molecular Systems Immunology and Physiology Research 2012-2017 250114

Childhood Diabetes Foundation

Skane County Council for Research and Development

UMAS Funds 

Available from: 2017-12-22 Created: 2017-12-22 Last updated: 2018-01-30Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Hyötyläinen, Tuulia

Search in DiVA

By author/editor
Hyötyläinen, Tuulia
By organisation
School of Science and TechnologySchool of Medical Sciences
In the same journal
Diabetes
Endocrinology and DiabetesImmunology in the medical areaPediatrics

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 52 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf