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Effects of whole grain, fish and bilberries on serum metabolic profile and lipid transfer protein activities: a randomized trial (Sysdimet)
Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland; VTT, Technical Research Centre of Finland, Kuopio, Finland.
Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
Department of Clinical Nutrition, Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
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2014 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 9, no 2, article id e90352Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: We studied the combined effects of wholegrain, fish and bilberries on serum metabolic profile and lipid transfer protein activities in subjects with the metabolic syndrome.

METHODS: Altogether 131 subjects (40-70 y, BMI 26-39 kg/m(2)) with impaired glucose metabolism and features of the metabolic syndrome were randomized into three groups with 12-week periods according to a parallel study design. They consumed either: a) wholegrain and low postprandial insulin response grain products, fatty fish 3 times a week, and bilberries 3 portions per day (HealthyDiet), b) wholegrain and low postprandial insulin response grain products (WGED), or c) refined wheat breads as cereal products (Control). Altogether 106 subjects completed the study. Serum metabolic profile was studied using an NMR-based platform providing information on lipoprotein subclasses and lipids as well as low-molecular-weight metabolites.

RESULTS: There were no significant differences in clinical characteristics between the groups at baseline or at the end of the intervention. Mixed model analyses revealed significant changes in lipid metabolites in the HealthyDiet group during the intervention compared to the Control group. All changes reflected increased polyunsaturation in plasma fatty acids, especially in n-3 PUFAs, while n-6 and n-7 fatty acids decreased. According to tertiles of changes in fish intake, a greater increase of fish intake was associated with increased concentration of large HDL particles, larger average diameter of HDL particles, and increased concentrations of large HDL lipid components, even though total levels of HDL cholesterol remained stable.

CONCLUSIONS: The results suggest that consumption of diet rich in whole grain, bilberries and especially fatty fish causes changes in HDL particles shifting their subclass distribution toward larger particles. These changes may be related to known protective functions of HDL such as reverse cholesterol transport and could partly explain the known protective effects of fish consumption against atherosclerosis.

TRIAL REGISTRATION: The study was registered at ClinicalTrials.gov NCT00573781.

Place, publisher, year, edition, pages
Public Library of Science , 2014. Vol. 9, no 2, article id e90352
National Category
Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:oru:diva-63693DOI: 10.1371/journal.pone.0090352ISI: 000332396200178PubMedID: 24587337Scopus ID: 2-s2.0-84896512072OAI: oai:DiVA.org:oru-63693DiVA, id: diva2:1169258
Note

Funding agencies:

Academy of Finland 117844 118590 117996 131460 137870 257545

European Commission FOOD-CT-2005-514008

Kuopio University Hospital 5106 5168 5254

Sigrid Juselius Foundation

TEKES - the Finnish Funding Agency for Technology and Innovation

University of Oulu

Finnish Diabetes Research Foundation

Nordic Centre of Excellence on Systems Biology in Controlled Dietary Intervention and Cohort Studies (SYSDIET) 070014

Fazer bakeries Oy

Vaasan Vaasan Oy

KE Leipa Oy

Leipomo Ruistahka

Leipomo Koskelonseutu

Raisio Oyj

Pakkasmarja Oy

Joswola Oy

Available from: 2017-12-22 Created: 2017-12-22 Last updated: 2018-01-23Bibliographically approved

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Oresic, Matej

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