oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Isoenergetic diets differing in their n-3 fatty acid and polyphenol content reflect different plasma and HDL-fraction lipidomic profiles in subjects at high cardiovascular risk
VTT Technical Research Centre of Finland, Espoo, Finland; Department of Food Science and Physiology, Research Building, University of Navarra, Pamplona, Spain.
VTT Technical Research Centre of Finland, Espoo, Finland.
Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
Show others and affiliations
2014 (English)In: Molecular Nutrition & Food Research, ISSN 1613-4125, E-ISSN 1613-4133, Vol. 58, no 9, p. 1873-1882Article in journal (Refereed) Published
Abstract [en]

SCOPE: Dysregulation of lipid homeostasis is related to multiple major healthcare problems. The aim of this study was to investigate the effects of n-3 fatty acid (FA) and polyphenol rich diets on plasma and HDL fraction lipidomic profiles in subjects at high cardiovascular risk.

METHODS AND RESULTS: Ultra performance LC coupled to quadrupole TOF/MS mass spectrometry global lipidomic profiling was applied to plasma and HDL fraction from an 8 wk randomized intervention with four isoenergetic diets, differing in their natural n-3 FA and polyphenols content, in 78 subjects with a high BMI, abdominal obesity, and at least one other feature of the metabolic syndrome. Dependency network analysis showed a different pattern of associations between lipidomics, dietary, and clinical variables after the dietary interventions. The most remarkable associations between variables were observed after the diet high in n-3 FA and polyphenols, as the inverse association between gallic acid intake and LDL cholesterol levels, which was indirectly associated with a HDL cluster exclusively comprised lysophospholipids.

CONCLUSION: This is the first human randomized controlled trial showing direct and indirect associations with lipid molecular species and clinical variables of interest in the evaluation of the metabolic syndrome after diets naturally rich in polyphenols.

Place, publisher, year, edition, pages
American Chemical Society (ACS), 2014. Vol. 58, no 9, p. 1873-1882
Keywords [en]
Cardiovascular disease, Lipidomics, Plasmalogens, Polyphenols, n-3 fatty acids
National Category
Nutrition and Dietetics Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:oru:diva-63694DOI: 10.1002/mnfr.201400155ISI: 000341885700011PubMedID: 24961394Scopus ID: 2-s2.0-84908180728OAI: oai:DiVA.org:oru-63694DiVA, id: diva2:1169259
Funder
EU, FP7, Seventh Framework Programme, FP7-KBBE-222639Available from: 2017-12-22 Created: 2017-12-22 Last updated: 2018-01-30Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Hyötyläinen, TuuliaOresic, Matej

Search in DiVA

By author/editor
Hyötyläinen, TuuliaOresic, Matej
By organisation
School of Science and TechnologySchool of Medical Sciences
In the same journal
Molecular Nutrition & Food Research
Nutrition and DieteticsCardiac and Cardiovascular Systems

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 27 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf