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Roux-en-Y Gastric Bypass Surgery Induces Early Plasma Metabolomic and Lipidomic Alterations in Humans Associated with Diabetes Remission
Department of Molecular and Clinical Medicine, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden.
VTT Technical Research Centre of Finland, Espoo, Finland; Metabolomics Unit, Institute for Molecular Medicine Finland FIMM, Helsinki, Finland.
Department of Bariatric Surgery, Musgrove Park Hospital, Taunton, United Kingdom.
Department of Bariatric Surgery, Musgrove Park Hospital, Taunton, United Kingdom.
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2015 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 10, no 5, article id e0126401Article in journal (Refereed) Published
Abstract [en]

Roux-en-Y gastric bypass (RYGB) is an effective method to attain sustained weight loss and diabetes remission. We aimed to elucidate early changes in the plasma metabolome and lipidome after RYGB. Plasma samples from 16 insulin-resistant morbidly obese subjects, of whom 14 had diabetes, were subjected to global metabolomics and lipidomics analysis at pre-surgery and 4 and 42 days after RYGB. Metabolites and lipid species were compared between time points and between subjects who were in remission and not in remission from diabetes 2 years after surgery. We found that the variables that were most discriminatory between time points were decanoic acid and octanoic acid, which were elevated 42 days after surgery, and sphingomyelins (18:1/21:0 and 18:1/23:3), which were at their lowest level 42 days after surgery. Insulin levels were lower at 4 and 42 days after surgery compared with pre-surgery levels. At 4 days after surgery, insulin levels correlated positively with metabolites of branched chain and aromatic amino acid metabolism and negatively with triglycerides with long-chain fatty acids. Of the 14 subjects with diabetes prior to surgery, 7 were in remission 2 years after surgery. The subjects in remission displayed higher pre-surgery levels of tricarboxylic acid cycle intermediates and triglycerides with long-chain fatty acids compared with subjects not in remission. Thus, metabolic alterations are induced soon after surgery and subjects with diabetes remission differ in the metabolic profiles at pre- and early post-surgery time points compared to patients not in remission.

Place, publisher, year, edition, pages
Public Library of Science , 2015. Vol. 10, no 5, article id e0126401
National Category
Endocrinology and Diabetes Nutrition and Dietetics
Identifiers
URN: urn:nbn:se:oru:diva-63704DOI: 10.1371/journal.pone.0126401ISI: 000354049700126PubMedID: 25946120Scopus ID: 2-s2.0-84929147898OAI: oai:DiVA.org:oru-63704DiVA, id: diva2:1169269
Funder
Swedish Research CouncilSwedish Diabetes AssociationSwedish Foundation for Strategic Research Swedish Heart Lung FoundationEU, FP7, Seventh Framework Programme, FP7-KBBE-222639Region Västra GötalandRegion Västra GötalandEU, FP7, Seventh Framework ProgrammeSwedish Heart Lung FoundationSwedish Foundation for Strategic Research Swedish Diabetes AssociationSwedish Research Council
Note

Funding agencies:

Human Frontier of Science Program RGY64/2008 

Available from: 2017-12-22 Created: 2017-12-22 Last updated: 2018-04-07Bibliographically approved

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Oresic, Matej

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