oru.sePublications
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
The influence of sample collection methodology and sample preprocessing on the blood metabolic profile.
Department of Pediatric Research, Oslo University Hospital, Oslo, Norway.
Finnish Food Safety Authority Evira, Helsinki, Finland.
Steno Diabetes Center, Gentofte, Denmark.
Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Finland.
Show others and affiliations
2015 (English)In: Bioanalysis, ISSN 1757-6180, E-ISSN 1757-6199, Vol. 7, no 8, p. 991-1006Article in journal (Refereed) Published
Abstract [en]

AIM: Blood serum and plasma have intrinsic differences in their composition and the preprocessing, such as clotting temperature in serum, and storage at room temperature may have further effect on metabolite concentrations.

METHODS: The influence of sampling preprocessing on the metabolic profiles in serum and different types of plasma was investigated using liquid chromatography and comprehensive 2D gas chromatography coupled to a mass spectrometer.

RESULTS: The profiles of polar metabolites were significantly dependent on the type of the sample, while lipid profiles were similar in serum and different types of plasma. Extended storage of plasma at room temperature resulted in degradation of lipids already after 1 day. Serum clotting at room temperature generally resulted in higher metabolite concentration compared with serum clotting on ice.

Place, publisher, year, edition, pages
Future Science Ltd. , 2015. Vol. 7, no 8, p. 991-1006
National Category
Analytical Chemistry
Identifiers
URN: urn:nbn:se:oru:diva-63705DOI: 10.4155/bio.15.16ISI: 000354554500008PubMedID: 25966010Scopus ID: 2-s2.0-84929353496OAI: oai:DiVA.org:oru-63705DiVA, id: diva2:1169270
Funder
EU, FP7, Seventh Framework Programme, FP7-KBBE-222639 FP7-KBBE-222720
Note

Funding agencies:

Norwegian Research Council 214191 

Available from: 2017-12-22 Created: 2017-12-22 Last updated: 2018-01-30Bibliographically approved

Open Access in DiVA

No full text in DiVA

Other links

Publisher's full textPubMedScopus

Authority records BETA

Oresic, MatejHyötyläinen, Tuulia

Search in DiVA

By author/editor
Oresic, MatejHyötyläinen, Tuulia
By organisation
School of Medical SciencesSchool of Science and Technology
In the same journal
Bioanalysis
Analytical Chemistry

Search outside of DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric score

doi
pubmed
urn-nbn
Total: 25 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf