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Obesity and psychotic disorders: uncovering common mechanisms through metabolomics
Örebro University, School of Medical Sciences. Systems Biology and Bioinformatics, VTT Technical Research Centre of Finland, Espoo, Finland.ORCID iD: 0000-0002-2856-9165
2012 (English)In: Disease Models and Mechanisms, ISSN 1754-8403, E-ISSN 1754-8411, Vol. 5, no 5, p. 614-620Article in journal (Refereed) Published
Abstract [en]

Primary obesity and psychotic disorders are similar with respect to the associated changes in energy balance and co-morbidities, including metabolic syndrome. Such similarities do not necessarily demonstrate causal links, but instead suggest that specific causes of and metabolic disturbances associated with obesity play a pathogenic role in the development of co-morbid disorders, potentially even before obesity develops. Metabolomics - the systematic study of metabolites, which are small molecules generated by the process of metabolism - has been important in elucidating the pathways underlying obesity-associated co-morbidities. This review covers how recent metabolomic studies have advanced biomarker discovery and the elucidation of mechanisms underlying obesity and its co-morbidities, with a specific focus on metabolic syndrome and psychotic disorders. The importance of identifying metabolic markers of disease-associated intermediate phenotypes - traits modulated but not encoded by the DNA sequence - is emphasized. Such markers would be applicable as diagnostic tools in a personalized healthcare setting and might also open up novel therapeutic avenues.

Place, publisher, year, edition, pages
The Company of Biologists , 2012. Vol. 5, no 5, p. 614-620
National Category
Biochemistry and Molecular Biology Endocrinology and Diabetes Diagnostic Biotechnology
Identifiers
URN: urn:nbn:se:oru:diva-63730DOI: 10.1242/dmm.009845ISI: 000308737400010PubMedID: 22915023Scopus ID: 2-s2.0-84865498638OAI: oai:DiVA.org:oru-63730DiVA, id: diva2:1169318
Funder
EU, FP7, Seventh Framework Programme, FP7-KBBE-222639
Note

Funding agencies:

Academy of Finland Centre of Excellence in Molecular Systems Immunology and Physiology Research (SyMMyS) 250114

Available from: 2017-12-23 Created: 2017-12-23 Last updated: 2018-02-19Bibliographically approved

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Oresic, Matej

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