The association between p,p'-DDE levels and left ventricular mass is mainly mediated by obesityShow others and affiliations
2018 (English)In: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 160, p. 541-546Article in journal (Refereed) Published
Abstract [en]
BACKGROUND AND OBJECTIVES: The pesticide metabolite p,p'-DDE has been associated with left ventricular (LV) mass and known risk factors for LV hypertrophy in humans and in experimental models. We hypothesized that the associations of p,p'-DDE with LV hypertrophy risk factors, namely elevated glucose, adiposity and hypertension, mediate the association of p,p'-DDE with LV mass.
METHODS: p,p'-DDE was measured in plasma from 70-year-old subjects (n = 988) of the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). When these subjects were 70-, 75- and 80- years old, LV characteristics were measured by echocardiography, while fasting glucose, body mass index (BMI) and blood pressure were assessed with standard clinical techniques.
RESULTS: We found that p,p'-DDE levels were associated with increased fasting glucose, BMI, hypertension and LV mass in separate models adjusted for sex. Structural equation modeling revealed that the association between p,p'-DDE and LV mass was almost entirely mediated by BMI (70%), and also by hypertension (19%).
CONCLUSION: The obesogenic effect of p,p'-DDE is a major determinant responsible for the association of p,p'-DDE with LV mass.
Place, publisher, year, edition, pages
Academic Press, 2018. Vol. 160, p. 541-546
Keywords [en]
Glucose, Hypertension, Left ventricular hypertrophy, Obesity, P, p′-DDE
National Category
Cardiac and Cardiovascular Systems Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:oru:diva-62384DOI: 10.1016/j.envres.2017.10.031ISI: 000417548600058PubMedID: 29106953Scopus ID: 2-s2.0-85032660018OAI: oai:DiVA.org:oru-62384DiVA, id: diva2:1170244
Funder
Swedish Research Council, 2012-2407Swedish Research Council Formas, 2007-2047
Note
Funding agencies:
USDA National Institute of Food and Agriculture 1002182
National Institutes of Health ES019919 ES023513
2018-01-022018-01-022018-09-12Bibliographically approved