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The association between p,p'-DDE levels and left ventricular mass is mainly mediated by obesity
Department of Environmental Toxicology, University of California, Davis CA, USA.
Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
Örebro University, School of Science and Technology. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden; Norwegian Institute for Water Research, NIVA, Oslo, Norway. (MTM Research Centre)ORCID iD: 0000-0001-5752-4196
Örebro University, School of Science and Technology. Norwegian Institute for Water Research, NIVA, Oslo, Norway. (MTM Research Centre)ORCID iD: 0000-0001-6217-8857
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2018 (English)In: Environmental Research, ISSN 0013-9351, E-ISSN 1096-0953, Vol. 160, 541-546 p.Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND OBJECTIVES: The pesticide metabolite p,p'-DDE has been associated with left ventricular (LV) mass and known risk factors for LV hypertrophy in humans and in experimental models. We hypothesized that the associations of p,p'-DDE with LV hypertrophy risk factors, namely elevated glucose, adiposity and hypertension, mediate the association of p,p'-DDE with LV mass.

METHODS: p,p'-DDE was measured in plasma from 70-year-old subjects (n = 988) of the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS). When these subjects were 70-, 75- and 80- years old, LV characteristics were measured by echocardiography, while fasting glucose, body mass index (BMI) and blood pressure were assessed with standard clinical techniques.

RESULTS: We found that p,p'-DDE levels were associated with increased fasting glucose, BMI, hypertension and LV mass in separate models adjusted for sex. Structural equation modeling revealed that the association between p,p'-DDE and LV mass was almost entirely mediated by BMI (70%), and also by hypertension (19%).

CONCLUSION: The obesogenic effect of p,p'-DDE is a major determinant responsible for the association of p,p'-DDE with LV mass.

Place, publisher, year, edition, pages
Academic Press, 2018. Vol. 160, 541-546 p.
Keyword [en]
Glucose, Hypertension, Left ventricular hypertrophy, Obesity, P, p′-DDE
National Category
Cardiac and Cardiovascular Systems Occupational Health and Environmental Health
Identifiers
URN: urn:nbn:se:oru:diva-62384DOI: 10.1016/j.envres.2017.10.031ISI: 000417548600058PubMedID: 29106953Scopus ID: 2-s2.0-85032660018OAI: oai:DiVA.org:oru-62384DiVA: diva2:1170244
Funder
Swedish Research Council, 2012-2407Swedish Research Council Formas, 2007-2047
Note

Funding agencies:

USDA National Institute of Food and Agriculture 1002182

National Institutes of Health ES019919 ES023513

Available from: 2018-01-02 Created: 2018-01-02 Last updated: 2018-01-13Bibliographically approved

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Salihovic, Samiravan Bavel, Bert

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