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Inflammasome activation, colonic cancer and glucose metabolism
Örebro University, School of Medical Sciences. Department of Surgery, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.
Örebro University, School of Medical Sciences. Department of Surgery, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.ORCID iD: 0000-0003-2636-4745
Örebro University, School of Medical Sciences. iRiSC – Inflammatory Response and Infection Susceptibility Centre, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.ORCID iD: 0000-0002-4319-7208
2016 (English)In: Clinical Nutrition ESPEN, ISSN 2405-4577, Vol. 12, article id e37Article in journal (Refereed) Published
Abstract [en]

Objectives: To study the association between inflammasome activation (a potent initiator of inflammation acting via caspase-1 and maturation of interleukin-1β), colonic cancer and glucose metabolism.

Methods: Five patients with colon cancer and ten matched controls without cancer were measured for insulin sensitivity using the hyperinsulinemic euglycemic clamp. For detection of inflammasome activation the caspase-1 activity, determined by detecting FLICA using flow cytometry, was measured in both monocytes and granulocytes at the start of, and at 120 minutes into the clamp. Descriptive and analytical statistics were performed using nonparametric methods by SPSS.

Results: There was no difference in levels of insulin sensitivity between the two groups (p=0.09). The cancer patients had significantly lower levels of caspase-1 both in monocytes (p<0.05) and granulocytes (p<0.05) compared with the controls. However both patients and controls had significantly higher levels of both mono- and granulocyte caspase-1 activity at 120 minutes into the clamp as compared to at start (p<0.05). Patients showed an overall higher relative increase in caspase-1 during the clamp, however this finding did not reach statistical significance (monocytes; p=0.27, granulocytes; p=0.22).

Place, publisher, year, edition, pages
Elsevier, 2016. Vol. 12, article id e37
National Category
Cancer and Oncology Other Clinical Medicine
Identifiers
URN: urn:nbn:se:oru:diva-63767DOI: 10.1016/j.clnesp.2016.02.026PubMedID: 28531688OAI: oai:DiVA.org:oru-63767DiVA, id: diva2:1170357
Available from: 2018-01-03 Created: 2018-01-03 Last updated: 2018-07-24Bibliographically approved

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Baban, BayarLjungqvist, OlleSärndahl, Eva

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