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Nutritional status and endocrine response to haemorrhage
Örebro University, School of Medical Sciences. Department of Surgery, Karolinska Hospital, Stockholm, Sweden.ORCID iD: 0000-0003-2636-4745
Department of Surgery, Karolinska Hospital, Stockholm, Sweden.
Department of Surgery, Karolinska Hospital, Stockholm, Sweden.
Department of Surgery, Karolinska Hospital, Stockholm, Sweden.
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1986 (English)In: Canadian Journal of Physiology and Pharmacology, ISSN 0008-4212, E-ISSN 1205-7541, Vol. 64, no 8, p. 1185-1188Article in journal (Refereed) Published
Abstract [en]

Hyperglycemia-inducing hyperosmolality has recently been proven beneficial in the maintenance of blood volume and extracellular fluid volume during early hemorrhagic hypotension. Fed animals benefitted from better plasma refill compared with starved ones when subjected to equal blood loss. Using lightly sedated fed and 24-30 h starved rats, hormones with relevance to glucose homeostasis were studied during 90 min of hemorrhagic hypotension of 70 mmHg (1 mmHg = 133.32 Pa). Marked differences in the overall hormonal developments were found between the two groups. In fed rats, insulin and glucagon responses were initially attenuated, while somatostatin increased to an early peak level at 30 min, returning to basal at 90 min. In starved rats, somatostatin increased gradually during the 90 min. Adrenaline release was massive in both groups. Corticosterone showed no increase from basal levels in the fed group during hemorrhage, while starved rats increased their basal level fourfold already at 30 min. These data are presented as evidence that changing nutritional status alters hormonal response to hypovolemic stress.

Place, publisher, year, edition, pages
NRC Research Press, 1986. Vol. 64, no 8, p. 1185-1188
National Category
Surgery Physiology
Identifiers
URN: urn:nbn:se:oru:diva-63829ISI: A1986E677500006PubMedID: 2877724Scopus ID: 2-s2.0-0022970387OAI: oai:DiVA.org:oru-63829DiVA, id: diva2:1170846
Available from: 2018-01-04 Created: 2018-01-04 Last updated: 2018-02-01Bibliographically approved

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Ljungqvist, Olle

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