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Effect of food deprivation on survival after haemorrhage in the rat
Örebro University, School of Medical Sciences. Department of Surgery, Karolinska Hospital, Stockholm, Sweden.ORCID iD: 0000-0003-2636-4745
Department of Surgery, Karolinska Hospital, Stockholm, Sweden.
Department of Surgery, Karolinska Hospital, Stockholm, Sweden.
1987 (English)In: Circulatory Shock, ISSN 0092-6213, Vol. 22, no 3, p. 251-260Article in journal (Refereed) Published
Abstract [en]

The changes in plasma glucose concentration and hematocrit during, and 7-day survivalafter, 60-min hemorrhagic hypotension (55 mmHg MAP) were investigated in postprandial and 6- or 24-h food-deprived rats. During hemorrhage, postprandial rats developed hyperglycemia, 30% greater than 6-h and 150% higher than 24-h food-deprived rats. Blood loss and plasma refill were greater in postprandial rats compared to 24-h food-deprived rats. Food deprivation for 24 h resulted in significantly increased mortality (6/13) posthemorrhage. All postprandial rats survived (13/13). A further three groups of animals deprived of food for 24 h were submitted to hemorrhage volume similar to that of postprandial rats. When no infusion was given during hemorrhage all rats died after hemorrhage (10/10). Saline infusion did not increase survival. Infusion of a similar volume of hypertonic glucose resulted in improved survival (not significant vs postprandial). Short-term food deprivation alters responses to stress and influences the outcome after standardized hemorrhage. Induction of hyperglycemia during hemorrhage was associated with survival.

Place, publisher, year, edition, pages
Wiley-Liss , 1987. Vol. 22, no 3, p. 251-260
National Category
Surgery
Identifiers
URN: urn:nbn:se:oru:diva-63830ISI: A1989AG88800004PubMedID: 3621480Scopus ID: 2-s2.0-0023273774OAI: oai:DiVA.org:oru-63830DiVA, id: diva2:1170849
Available from: 2018-01-04 Created: 2018-01-04 Last updated: 2018-02-01Bibliographically approved

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