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Evidence of increased gluconeogenesis during hemorrhage in fed and 24-hour food-deprived rats
Örebro University, School of Medical Sciences. Department of Surgery, Karolinska Hospital, Stockholm, Sweden.ORCID iD: 0000-0003-2636-4745
Department of Surgery, Karolinska Hospital, Stockholm, Sweden.
Department of Surgery, Karolinska Hospital, Stockholm, Sweden.
1989 (English)In: Journal of Trauma and Acute Care Surgery, ISSN 2163-0755, E-ISSN 2163-0763, Vol. 29, no 1, p. 87-90Article in journal (Refereed) Published
Abstract [en]

Food withdrawal 24 hr before hemorrhage has been shown to increase experimental post-hemorrhage mortality, and survival is associated with the degree of hyperglycemia. Lack of hyperglycemic response has been attributed to depleted glycogen reserves after 24-hr food withdrawal. To investigate the effect of short-term food deprivation on glucose metabolism during hemorrhagic stress, glucose production (rate of appearance, Ra), glucose uptake (rate of disappearance, Rd), glucose clearance, and glucose recycling were investigated in fed and 24-hr food-deprived rats under basal conditions, and during hemorrhagic hypotension using 3-H3-U-C14-glucose. During hemorrhage, blood glucose levels were higher in fed rats. Hemorrhage induced a decrease in glucose clearance irrespective of nutritional state in both 24-hr starved animals and rats in the postprandial state. Calculated glucose recycling increased in both groups after hemorrhage. The results indicate that hemorrhagic stress induces a rapid increase in gluconeogenesis, as reflected by increased glucose recycling.

Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 1989. Vol. 29, no 1, p. 87-90
National Category
Physiology
Identifiers
URN: urn:nbn:se:oru:diva-63834DOI: 10.1097/00005373-198901000-00018ISI: A1989R947800018PubMedID: 2911109Scopus ID: 2-s2.0-0024502792OAI: oai:DiVA.org:oru-63834DiVA, id: diva2:1170918
Available from: 2018-01-05 Created: 2018-01-05 Last updated: 2018-02-06Bibliographically approved

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Ljungqvist, Olle

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