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Endotoxin, epinephrine, glucagon, insulin and calcium ionophore A23187 modulation of kinese activity in cultured rat hepatocytes
Department of Clinical Immunology and Transfusion Medicine, University Hospital, Uppsala, Sweden.
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1990 (English)In: Acta Chirurgica Scandinavica, ISSN 0001-5482, p. 677-681Article in journal (Refereed) Published
Abstract [en]

Altered glucose metabolism is one of the commonly observed sequelae of sepsis and septic shock. The present investigation was undertaken to determine the role of endotoxin (ET) upon hepatocyte glucoregulation, by measuring the activity of pyruvate kinase (PK), a key glycolytic enzyme. Hepatocytes were exposed to endotoxin concentrations known to occur in vivo during sepsis, i.e., from 1 X 10(-14) to 1 X 10(-8) g/ml. The alteration of the enzyme activities after addition of epinephrine, glucagon, insulin and calcium ionophore A23187 with and without ET preincubation were also examined. ET alone decreased the PK activity by 12% at all concentrations tested. The basal inhibition of the enzyme caused by epinephrine (-48%) was partially blocked by ET preincubation above 1 X 10(-10) g/ml. There were no ET-(glucagon, calcium ionophore, insulin) interaction. These in vitro results do not support pyruvate kinase as a site of hepatic enzyme regulation defect in endotoxaemia.

Place, publisher, year, edition, pages
Taylor & Francis, 1990. p. 677-681
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Medical and Health Sciences Surgery
Identifiers
URN: urn:nbn:se:oru:diva-63836ISI: A1990EK21500003PubMedID: 2264425Scopus ID: 2-s2.0-0025167786OAI: oai:DiVA.org:oru-63836DiVA, id: diva2:1170923
Available from: 2018-01-05 Created: 2018-01-05 Last updated: 2018-02-09Bibliographically approved

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Ljungqvist, Olle

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