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Hyperglycemia and survival after haemorrhage
Department of Surgery, Karolinska Hospital and Institute, Stockholm, Sweden.ORCID iD: 0000-0003-2636-4745
1994 (English)In: European Journal of Surgery, ISSN 1102-4151, E-ISSN 1741-9271, Vol. 160, no 9, p. 465-469Article in journal (Refereed) Published
Abstract [en]

Objective: To assess the relation between the degree of hyperglycaemia during a standard haemorrhage and survival.

Design: Prospective laboratory studySetting: University department of surgery, Sweden.

Material: 5 groups of 8-12 adult male Sprague-Dawley rats.

Interventions: Different degrees of hyperglycaemia were achieved in the 5 groups of rats (which had been starved for 24 hours) by infusion of the same amount of 0.9% saline, or 5%, 10%, 20% or 30% glucose during a 48% standard haemorrhage over 60 minutes. Blood glucose concentration and packed cell volume were measured every 30 minutes, and mean arterial pressure was monitored constantly.

Main Outcome Measure: Survival at 7 days.

Results: Increases in blood glucose concentrations during haemorrhage correlated with plasma refill as indicated by reductions in packed cell volume (r = 0.85, p < 0.0001). Both increases in blood glucose concentrations and reductions in packed cell volume were inversely related to blood pressure during haemorrhage (p < 0.0001). The more glucose that was infused, the higher the blood glucose concentration and the better the plasma refill during haemorrhage which correlated with improvement in the rate of survival at 7 days (p < 0.001).

Conclusion: The ability to mount a hyperglycaemic response is an important prognostic factor in survival after experimental haemorrhage.

Place, publisher, year, edition, pages
Taylor & Francis, 1994. Vol. 160, no 9, p. 465-469
National Category
Medical and Health Sciences Surgery
Identifiers
URN: urn:nbn:se:oru:diva-63850ISI: A1994PL46600001PubMedID: 7849164OAI: oai:DiVA.org:oru-63850DiVA, id: diva2:1170961
Available from: 2018-01-05 Created: 2018-01-05 Last updated: 2018-02-09Bibliographically approved

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Ljungqvist, Olle

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