Themetabolic response to cholecystectomy; insulin resitance after open vs.laparoscopic surgeryShow others and affiliations
1995 (English)In: European Journal of Surgery, ISSN 1102-4151, E-ISSN 1741-9271, Vol. 162, no 3, p. 187-191Article in journal (Refereed) Published
Abstract [en]
Objective. To study the changes in insulin sensitivity and plasma concentrations of interleukin-6 (IL-6) after open compared with laparoscopic cholecystectomy.
Design: Prospective open study.
Setting: University hospital, Sweden.
Subjects: 12 otherwise healthy patients undergoing either open (n = 6) or laparoscopic (n = 6) cholecystectomy.
Main outcome measure: Relative insulin sensitivity (compared with preoperative) on the day after operation. Changes in IL-6 concentrations postoperatively.
Results. The mean (SEM) relative reduction in insulin sensitivity was significantly smaller after laparoscopic (18 (5)%) compared with the open operation, (58 (4)%) (p < 0.01). There was a significant increase in plasma concentrations of IL-6 postoperatively, but there was no difference between the groups.
Conclusion. Insulin sensitivity is less affected 24 hours after laparoscopic than after open cholecystectomy, which in this study was not accompanied by a simultaneous difference in the IL-6 response. The small postoperative reduction of insulin sensitivity may be a contributing factor to the clinical benefit of improved wellbeing observed after laparoscopic surgery.
Place, publisher, year, edition, pages
Taylor & Francis Scandinavia , 1995. Vol. 162, no 3, p. 187-191
National Category
Surgery
Identifiers
URN: urn:nbn:se:oru:diva-63864ISI: A1996UC09500005PubMedID: 8695732Scopus ID: 2-s2.0-0029867914OAI: oai:DiVA.org:oru-63864DiVA, id: diva2:1170996
2018-01-052018-01-052018-02-05Bibliographically approved