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Themetabolic response to cholecystectomy; insulin resitance after open vs.laparoscopic surgery
Department of Surgery, Karolinska Hospital and Institute, Stockholm, Sweden.
Department of Surgery, Karolinska Hospital and Institute, Stockholm, Sweden.
Department of Anaesthesia, Huddinge Hospital, Stockholm, Sweden.
Department of Endocrinology, Karolinska Hospital and Institute, Stockholm, Sweden.
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1995 (English)In: European Journal of Surgery, ISSN 1102-4151, E-ISSN 1741-9271, Vol. 162, no 3, p. 187-191Article in journal (Refereed) Published
Abstract [en]

Objective. To study the changes in insulin sensitivity and plasma concentrations of interleukin-6 (IL-6) after open compared with laparoscopic cholecystectomy.

Design: Prospective open study.

Setting: University hospital, Sweden.

Subjects: 12 otherwise healthy patients undergoing either open (n = 6) or laparoscopic (n = 6) cholecystectomy.

Main outcome measure: Relative insulin sensitivity (compared with preoperative) on the day after operation. Changes in IL-6 concentrations postoperatively.

Results. The mean (SEM) relative reduction in insulin sensitivity was significantly smaller after laparoscopic (18 (5)%) compared with the open operation, (58 (4)%) (p < 0.01). There was a significant increase in plasma concentrations of IL-6 postoperatively, but there was no difference between the groups.

Conclusion. Insulin sensitivity is less affected 24 hours after laparoscopic than after open cholecystectomy, which in this study was not accompanied by a simultaneous difference in the IL-6 response. The small postoperative reduction of insulin sensitivity may be a contributing factor to the clinical benefit of improved wellbeing observed after laparoscopic surgery.

Place, publisher, year, edition, pages
Taylor & Francis Scandinavia , 1995. Vol. 162, no 3, p. 187-191
National Category
Surgery
Identifiers
URN: urn:nbn:se:oru:diva-63864ISI: A1996UC09500005PubMedID: 8695732Scopus ID: 2-s2.0-0029867914OAI: oai:DiVA.org:oru-63864DiVA, id: diva2:1170996
Available from: 2018-01-05 Created: 2018-01-05 Last updated: 2018-02-05Bibliographically approved

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