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Modulating the insulin response to hemorrhage in the fasted rat with pre-stress glucose infusion
Department of Surgery, Karolinska Hospital, Sweden.ORCID iD: 0000-0003-2636-4745
1998 (English)In: Surgical communication Research, ISSN 0882-9233, Vol. 9, no 2-4, p. 85-96Article in journal (Refereed) Published
Abstract [en]

Elective surgery is usually performed after an overnight fast. Recent data suggests that pre-operative glucose loading instead of fasting is beneficial for postoperative metabolism by reducing insulin resistance. In this experimental study in rats, we examined the effects of pre-stress glucose infusion on the endocrine response to hemorrhage. Twenty-four hour food deprived rats received a 3 h continuous infusion of 30% glucose (0.3 mg/100 g b.wt./h) or the same volume of normal saline prior to standardized 35% blood loss during 60 min. Infusion of glucose resulted in a six fold increase in liver glycogen, and a twofold higher increment of blood glucose during hemorrhage, compared to saline treated rats. Animals given glucose developed a twofold increase in insulin during hemorrhage, which was not present in saline treated rats. Glucagon, catecholamines and corticosterone levels were elevated in a similar fashion in both groups during hemorrhage. These results indicate that the release of insulin in response to stress can be modulated by pre-treatment with glucose.

Place, publisher, year, edition, pages
Harwood Academic, 1998. Vol. 9, no 2-4, p. 85-96
Keywords [en]
Catecholamines, Corticosterone, Glucagon, Hemorrhage, Insulin, Liver glycogen, Rat
National Category
Medical and Health Sciences Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-63883Scopus ID: 2-s2.0-0031944399OAI: oai:DiVA.org:oru-63883DiVA, id: diva2:1171079
Available from: 2018-01-05 Created: 2018-01-05 Last updated: 2018-02-09Bibliographically approved

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Ljungqvist, Olle

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CiteExportLink to record
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  • nn-NB
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