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The effect of alpha 2 receptor agonists on central haemodynamic and blood glucose during hemorrhagic stress in the rat
Department of Surgery, Karolinska Hospital, Sweden.ORCID iD: 0000-0003-2636-4745
1998 (English)In: Surgical Research Communications, ISSN 0882-9233, Vol. 9, no 2-4, p. 151-164Article in journal (Refereed) Published
Abstract [en]

The effect of the selective alpha 2 agonist Mivazerol on catecholamine levels in plasma, and on central hemodynamics and blood glucose levels developments during hemorrhagic stress in rats was investigated. The animals were randomly given either saline, low dose of Mivazerol (0.6 μg/ml) or high dose (2.0 μg/ml) at a rate of 30 μl/100 g/min, beginning the infusions intravenously 30 min before onset and throughout 60 min of hemorrhagic stress. Before hemorrhage, Mivazerol raised mean arterial pressure, and reduced heart rate, adrenaline and noradrenaline levels in a dose dependent fashion. High dose infusion also resulted in an elevation in blood glucose. During hemorrhage, the high dose effectively dampened the catecholamine response. Simultaneously, the same group maintained better mean arterial pressure in response to hemorrhage. Blood glucose levels were elevated to similar levels regardless of treatment. These data indicate that Mivazerol effectively reduced the catecholamine response to severe hemorrhagic stress, while central hemodynamic and blood glucose responses were maintained or improved.

Place, publisher, year, edition, pages
Harwood Academic, 1998. Vol. 9, no 2-4, p. 151-164
Keywords [en]
Alpha 2 agonist, Glucose, Hemorrhage, Hypotension
National Category
Medical and Health Sciences Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-63884Scopus ID: 2-s2.0-0031898985OAI: oai:DiVA.org:oru-63884DiVA, id: diva2:1171080
Available from: 2018-01-05 Created: 2018-01-05 Last updated: 2018-02-09Bibliographically approved

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Ljungqvist, Olle

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