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Bulking fibre prevents translocation of an efficiently translocating Escherichia coli strain in rats
Departments of Surgery, Karolinska Institute, Stockholm, Sweden.
Department of Microbiology and Tumorbiology Center, Karolinska Institute, Stockholm, Sweden.
Departments of Surgery, Karolinska Institute, Stockholm, Sweden.
Departments of Surgery, Karolinska Institute, Stockholm, Sweden.
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1998 (English)In: Clinical Nutrition, ISSN 0261-5614, E-ISSN 1532-1983, Vol. 17, no 4, p. 185-190Article in journal (Refereed) Published
Abstract [en]

Background: starvation for 24 h prior to experimental haemorrhage increases bacterial translocation in rats. Forty-eight hours starvation alone causes pronounced microbiological changes in caecal contents and a marked increase in bacterial adherence to caecal epithelium. The aim of the present study was to examine whether bulking fibre prevents these microbiological changes induced by starvation, i.e. mucosal adherence and/or bacterial translocationwith and without haemorrhage in rats. Methods: 32 rats were inoculated with the translocating Escherichia cell strain KI-C1. Groups of these rats were then starved for 48 h with or without access to bulking fibre. An additional group of rats was given bulking fibre and subjected to haemorrhage. A control group was untreated and given regular food. Samples were taken from caecal contents, caecal epithelium, mesenteric lymph nodes and blood. A biochemical fingerprinting method was used to characterize and compare E. coil strains in all samples. Results: ingestion of bulking fibre alone for 48 h significantly reduced the frequency of KI-C1 both in caecal contents and on caecal epithelium and completely prevented translocation of the strain, compared to starvation without bulking fibre for 48 h. Enforced stress (haemorrhage) increased bacterial translocation to the same level as starvation for 48 h. E. coli phenotypes found in mesenteric lymph nodes were also found adhering to the caecal epithelium. Conclusions: the presence of bulking fibre in gut lumen, by unknown mechanisms, reduces the frequency of an inoculated translocating strain of E. coil in caecal contents and on caecal epithelium and prevents its translocationto mesenteric lymph nodes.

Place, publisher, year, edition, pages
Elsevier, 1998. Vol. 17, no 4, p. 185-190
National Category
Nutrition and Dietetics Physiology
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URN: urn:nbn:se:oru:diva-63887DOI: 10.1016/S0261-5614(98)80055-1ISI: 000076022600006PubMedID: 10205337Scopus ID: 2-s2.0-0031714590OAI: oai:DiVA.org:oru-63887DiVA, id: diva2:1171084
Available from: 2018-01-05 Created: 2018-01-05 Last updated: 2018-02-06Bibliographically approved

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