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Health-related quality of life in asthma patients: A comparison of two cohorts from 2005 and 2015
Örebro University, School of Medical Sciences. Department of Respiratory Medicine.
School of Medical Sciences, Örebro University, Örebro, Sweden.
Örebro University, School of Medical Sciences.
Örebro University, School of Medical Sciences. Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden; Clinical Epidemiology Unit, Department of Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College, London, UK.ORCID iD: 0000-0001-6328-5494
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2017 (English)In: Respiratory Medicine, ISSN 0954-6111, E-ISSN 1532-3064, Vol. 132, p. 154-160Article in journal (Refereed) Published
Abstract [en]

Introduction: The aim was to investigate temporal variation in Health-Related Quality of Life (HRQL) and factors influencing low HRQL, in patients with asthma.

Material and methods: Questionnaire data on patient characteristics and the mini-Asthma Quality of Life Questionnaire (mini-AQLQ) scores from two separate cohorts of randomly selected Swedish primary and secondary care asthma patients, in 2005 (n = 1034) and 2015 (n = 1126). Student's t-test and analysis of covariance with adjustment for confounders compared mini-AQLQ total and domain scores in 2005 and 2015. Multivariable linear regression analyzed associations with mini-AQLQ scores.

Results: The mean Mini-AQLQ scores were unchanged between 2005 and 2015 (adjusted means (95% CI) 2005: 5.39 (5.27-5.33) and in 2015: 5.44 (95% CI 5.32 to 5.38), p = 0.26). Overweight (regression coefficient 95% CI) (0.21 (-0.36 to -0.07)), obesity (-0.34 (-0,50 to -0.18)), one or more exacerbations during the previous six months (-0.64 (-0.79 to -0.50)), self-rated moderate/severe disease (-1.02 (-1.15 to-0.89)), heart disease (-0.42 (-0.68 to-0.16)), anxiety/depression (-0.31 (-0.48 to -0.13)) and rhinitis (-0.25 (-0.42 to -0.08)) were associated with lower HRQL. Higher educational level (0.32 (0.19-0.46)) and self-reported knowledge of self-management of exacerbations (0.35 (0.19-0.51)) were associated with higher HRQL.

Conclusions: HRQL in Swedish patients with asthma is generally good and unchanged during the last decade. Overweight, obesity, exacerbations, self-rated moderate/severe disease, heart disease, depression/anxiety and rhinitis were associated with lower HRQL, and high educational level and knowledge on self-management with higher HRQL.

Place, publisher, year, edition, pages
Saunders Elsevier, 2017. Vol. 132, p. 154-160
Keywords [en]
Asthma, Health-related quality of life, Mini-AQLQ, Risk factors
National Category
Cardiac and Cardiovascular Systems Respiratory Medicine and Allergy
Identifiers
URN: urn:nbn:se:oru:diva-63966DOI: 10.1016/j.rmed.2017.10.010ISI: 000418239100024PubMedID: 29229090Scopus ID: 2-s2.0-85032193787OAI: oai:DiVA.org:oru-63966DiVA, id: diva2:1172089
Funder
Swedish Heart Lung FoundationSwedish Asthma and Allergy Association
Note

Funding Agencies:

Uppsala-Örebro Health Care region

Bror Hjerpstedts Foundation  

Center for Clinical Research, Dalarna  

Region Örebro County through ALF 

Available from: 2018-01-09 Created: 2018-01-09 Last updated: 2018-01-09Bibliographically approved

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Sundh, JosefinHasselgren, MikaelMontgomery, Scott

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