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Totalparenteral nutrition after surgery rapidly increases serum leptin levels
Department of Paediatrics, Endocrine Research Unit, Huddinge University Hospital, Karolinska Institute, Huddinge, Sweden.
Department of Anaesthesiology and Intensive Care, Huddinge University Hospital, Karolinska Institute, Huddinge, Sweden.
Department of Paediatrics, Endocrine Research Unit, Huddinge University Hospital, Karolinska Institute, Huddinge, Sweden.
Department of Anaesthesiology and Intensive Care, Huddinge University Hospital, Karolinska Institute, Huddinge, Sweden.
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2001 (English)In: European Journal of Endocrinology, ISSN 0804-4643, E-ISSN 1479-683X, Vol. 144, no 2, p. 123-128Article in journal (Refereed) Published
Abstract [en]

Objective: In humans, leptin is regulated by long-term changes in energy intake. However, short-term regulation of serum leptin by nutrients has been difficult to show. The aim of this study was to investigate whether short periods of fasting and stress sensitise the leptin response to nutrients.

Subjects and experimental protocol: Fourteen patients of normal weight undergoing elective open cholecystectomy were randomised into two groups. One group received saline infusion during surgery and for 24 h postoperatively. The other group also received saline during the surgical procedure, but total parenteral (TPN) was started immediately after surgery. Blood samples were drawn before as well as 2, 4, 8, 16, and 24 h after the start of surgery to determine the serum levels of leptin and other hormones.

Results: Postoperative TPN induced a significant rise in serum leptin within 6 h, reaching a more than fourfold increase within 14 h (P < 0.001). Serum glucose and insulin levels increased within 2 h. Growth hormone and IGF-1 serum levels also increased significantly in the group receiving TPN. Serum cortisol levels increased postoperatively in both groups, which may explain why no significant reduction in serum leptin was observed in the group receiving saline. Free tri-iodothyronine (T3) decreased in both groups, while catecholamines were similar in the groups.

Conclusion: During fasting and surgical stress, nutrients rapidly increased the serum leptin levels in humans in a manner similar to that previously reported in rodents. This may be mediated by increases in serum glucose, insulin and cortisol.

Place, publisher, year, edition, pages
Bristol, NQ, USA: Bioscientifica, 2001. Vol. 144, no 2, p. 123-128
National Category
Medical and Health Sciences Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-64019DOI: 10.1530/eje.0.1440123ISI: 000167224900005PubMedID: 11182748Scopus ID: 2-s2.0-0035111312OAI: oai:DiVA.org:oru-64019DiVA: diva2:1172734
Available from: 2018-01-10 Created: 2018-01-10 Last updated: 2018-01-16Bibliographically approved

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