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Cognitive behavioral therapy for irritable bowel syndrome: the effects on state and trait anxiety and the autonomic nervous system during induced rectal distensions - An uncontrolled trial
Örebro University, School of Medical Sciences. Nutrition-Gut-Brain Interactions Research Centre.ORCID iD: 0000-0001-8451-6263
Örebro University, School of Law, Psychology and Social Work. (Center for Health and Medical Psychology (CHAMP))ORCID iD: 0000-0002-9462-0256
Department of Clinical Neuroscience, Division of Psychology and Division of Psychiatry, Karolinska Institutet, Stockholm, Sweden.
Örebro University, School of Law, Psychology and Social Work. (Center for Health and Medical Psychology (CHAMP))ORCID iD: 0000-0001-9429-9012
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2018 (English)In: Scandinavian Journal of Pain, ISSN 1877-8860, E-ISSN 1877-8879, Vol. 18, p. 81-91Article in journal (Refereed) Published
Abstract [en]

Background and aims: Irritable bowel syndrome (IBS), is a common multifactorial gastrointestinal disorder linked to disturbances in the microbe gut-brain axis. Cognitive behavioral therapy (CBT), in face-to-face format has showed promising results on IBS and its associated psychological symptoms. The present study explored for the first time if CBT for IBS affects the autonomic nervous system (ANS) during experimentally induced visceral pain and cognitive stress, respectively. The levels of state and trait anxiety, current and perceived stress were also evaluated.

Methods: In this uncontrolled trial, individual CBT was performed in face-to-face format for 12 weeks in 18 subjects with IBS. Heart rate variability and skin conductance were measured during experimentally induced visceral pain and during a cognitive task (Stroop color-word test), before and after intervention. The levels of state and trait anxiety as well as self-rated current and perceived stress were also measured before and after the intervention.

Results: CBT did not affect ANS activity during experimentally induced visceral pain and cognitive stress. The sympathetic activity was high, typical for IBS and triggered during both visceral pain and cognitive stress. The levels of state and trait anxiety significantly decreased after the intervention. No significant changes in self-rated current or perceived stress were found.

Conclusions: Results suggest that face-to-face CBT for IBS improved anxiety- a key psychological mechanism for the IBS pathophysiology, rather than the autonomic stress response to experimentally induced visceral pain and cognitive stress, respectively.

Place, publisher, year, edition, pages
Walter de Gruyter, 2018. Vol. 18, p. 81-91
Keywords [en]
irritable bowel syndrome; cognitive behavioral therapy; state anxiety; trait anxiety; stress; autonomic nervous system; visceral hypersensitivity
National Category
Neurology
Identifiers
URN: urn:nbn:se:oru:diva-64294DOI: 10.1515/sjpain-2017-0153ISI: 000426817200009Scopus ID: 2-s2.0-85043578532OAI: oai:DiVA.org:oru-64294DiVA, id: diva2:1174710
Available from: 2018-01-16 Created: 2018-01-16 Last updated: 2018-03-27Bibliographically approved

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Edebol-Carlman, HannaSchrooten, Martien G. S.Boersma, KatjaLinton, Steven J.Brummer, Robert Jan

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Edebol-Carlman, HannaSchrooten, Martien G. S.Boersma, KatjaLinton, Steven J.Brummer, Robert Jan
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