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Childhood Bereavement and Increased Sensitivity to Stress in Late Adolescence
Örebro University, School of Medical Sciences. Uppsala University, Uppsala, Sweden.ORCID iD: 0000-0002-0066-4814
Örebro University, School of Medical Sciences. Örebro University Hospital. Karolinska institutet, Stockholm, Sweden.
Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Centre of Public Health Sciences, Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavík, Iceland; Department of Epidemiology, Harvard Chan School of Public Health, Boston MA, USA.
Örebro University, School of Medical Sciences. Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden; Department of Epidemiology and Public Health, University College London, London, UK: Clinical Epidemiology Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden.ORCID iD: 0000-0001-6328-5494
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(English)Manuscript (preprint) (Other academic)
National Category
General Practice
Identifiers
URN: urn:nbn:se:oru:diva-64312OAI: oai:DiVA.org:oru-64312DiVA, id: diva2:1174790
Available from: 2018-01-16 Created: 2018-01-16 Last updated: 2018-01-16Bibliographically approved
In thesis
1. Childhood bereavement, stress resilience, and cancer risk: an integrated register-based approach
Open this publication in new window or tab >>Childhood bereavement, stress resilience, and cancer risk: an integrated register-based approach
2018 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Accumulating evidence suggests that psychosocial stress and susceptibility to stressful exposures – stress resilience – influence the risk of various health outcomes, but the potential link with cancer occurrence is unclear. The aims of this thesis were to test if loss of a close relative, a marker of severe psychological stress, and stress resilience measured during late adolescence are associated with cancer risk later in life, as well as to explore potential underlying mechanisms. National registers provided information on childhood bereavement, defined as death of a first-degree relative, as well as a measure of psychological functioning relevant to stress resilience that was obtained from mandatory military enlistment assessments. In a cohort comprising all individuals born in Sweden during 1961-2002, we found that bereavement during childhood (up to age 18 years) was associated with increased risks of HPVrelated malignancies and pancreatic cancer. Parental loss during early adulthood (ages 18-40 years) also entails a raised risk of pancreatic cancer as well as for gastric and lung cancer. In a cohort of men born during 1973-1983, we observed that childhood bereavement is also associated with low stress resilience during late adolescence. In our third cohort study, comprising men born during 1952-1956, we found that low stress resilience compared with high, was associated with 5-fold and 3-fold increased risks of subsequent liver and lung cancer, respectively. In contrast, low stress resilience is associated with reduced risks for prostate cancer and malignant melanoma. Finally, in a cohort of twin conscripts born during 1959-1985 who completed a survey in 2005- 2006 covering use of addictive substances, we found that low stress resilience was also associated with a raised occurrence of hazardous use of alcohol, alcohol dependence, cigarette smoking and nicotine dependence, as well as with other drug use. We conclude that the observed links with cancer risk for stressful exposures and low stress resilience, may be explained, at least in part, by disadvantageous health behavior.

Place, publisher, year, edition, pages
Örebro: Örebro University, 2018. p. 85
Series
Örebro Studies in Medicine, ISSN 1652-4063 ; 171
Keywords
alcohol, bereavement, cancer, drug use, epidemiology, health behaviour, psychological resilience, smoking, stress
National Category
General Practice
Identifiers
urn:nbn:se:oru:diva-62605 (URN)978-91-7529-224-3 (ISBN)
Public defence
2018-02-09, Campus USÖ, hörsal C1, Södra Grev Rosengatan 32, Örebro, 13:00 (English)
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Available from: 2017-11-16 Created: 2017-11-16 Last updated: 2018-01-19Bibliographically approved

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