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Perspectives on Systems Modeling of Human Peripheral Blood Mononuclear Cells
Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
Örebro University, School of Medical Sciences. Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.ORCID iD: 0000-0002-2856-9165
2018 (English)In: Frontiers in Molecular Biosciences, E-ISSN 2296-889X, Vol. 4, article id 96Article, review/survey (Refereed) Published
Abstract [en]

Human peripheral blood mononuclear cells (PBMCs) are the key drivers of the immune responses. These cells undergo activation, proliferation and differentiation into various subsets. During these processes they initiate metabolic reprogramming, which is coordinated by specific gene and protein activities. PBMCs as a model system have been widely used to study metabolic and autoimmune diseases. Herein we review various omics and systems-based approaches such as transcriptomics, epigenomics, proteomics, and metabolomics as applied to PBMCs, particularly T helper subsets, that unveiled disease markers and the underlying mechanisms. We also discuss and emphasize several aspects of T cell metabolic modeling in healthy and disease states using genome-scale metabolic models.

Place, publisher, year, edition, pages
Frontiers Research Foundation , 2018. Vol. 4, article id 96
Keywords [en]
Systems biology, multi-omics, peripheral blood mononuclear cells, PBMCs, immune system, metabolomics, genome-scale metabolic models, pathways
National Category
Bioinformatics and Systems Biology
Identifiers
URN: urn:nbn:se:oru:diva-64338DOI: 10.3389/fmolb.2017.00096OAI: oai:DiVA.org:oru-64338DiVA, id: diva2:1175064
Available from: 2018-01-17 Created: 2018-01-17 Last updated: 2018-01-19Bibliographically approved

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Oresic, Matej

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