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Effects on repetitive 24-hour ambulatory blood pressure in type 2 diabetic subjects randomized to liraglutide or glimepiride treatment both in combination with metformin: A randomized open parallel-group study
Örebro University, School of Medical Sciences.ORCID iD: 0000-0003-1025-1682
Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Örebro University, School of Medical Sciences. Örebro University Hospital. Unit of Biostatistics, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. (Clinical Epidemiology and Biostatistics)ORCID iD: 0000-0002-3552-9153
Central Hospital, Karlstad, Sweden.
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2018 (English)In: Journal of the American Society of Hypertension : JASH, ISSN 1933-1711, E-ISSN 1878-7436, Vol. 12, no 5, p. 346-355Article in journal (Refereed) Published
Abstract [en]

In this post hoc study, we aimed to investigate liraglutide treatment on repetitive 24-hour blood pressure (BP) in patients with type II diabetes. Sixty-two individuals with type II diabetes (45 males) were randomized to 1.8 mg liraglutide once daily or 4 mg glimepiride together with 1 g metformin twice daily. Ambulatory 24-hour systolic and diastolic blood pressure (sBP/dBP) was repetitively measured at baseline, 2 weeks, and 18 weeks. Outcomes were evaluated as treatment change from baseline, 2 weeks, and 18 weeks. Baseline clinical characteristics of liraglutide (n = 33) and glimepiride (n = 29) groups were well matched. No statistically significant difference in 24-hour sBP/dBP between three time periods and groups was observed. There was no treatment change for 24-hour sBP at week 2 or after week 18. There was a transient treatment change in 24-hour dBP in the liraglutide group at week 2 (3.2 ± 5.4 vs. -1.2 ± 4.5 mm Hg, P < .01). A treatment change in 24-hour heart rate at week 2 (4.9 ± 6.8 vs. 1.0 ± 6.0 bpm, P = .03) and at week 18 (5.9 ± 7.8 vs. 0.2 ± 6.3 bpm, P < .01) was observed in the liraglutide group. In conclusion, liraglutide treatment did not lower BP. However, a small diurnal variation in dBP without affecting BP variability or nocturnal BP dipping was observed.

Place, publisher, year, edition, pages
Elsevier, 2018. Vol. 12, no 5, p. 346-355
Keywords [en]
AMBP, GLP-1 RA, sulfonurea, type 2 diabetes
National Category
Endocrinology and Diabetes Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:oru:diva-64491DOI: 10.1016/j.jash.2018.02.003ISI: 000432644100006PubMedID: 29548934Scopus ID: 2-s2.0-85043460083OAI: oai:DiVA.org:oru-64491DiVA, id: diva2:1177122
Funder
Swedish Society for Medical Research (SSMF)Swedish Society of MedicineSwedish Heart Lung FoundationNovo NordiskStockholm County CouncilThe Karolinska Institutet's Research Foundation
Note

Funding Agency:

Stiftelsen Serafimerlasarettet

Available from: 2018-01-24 Created: 2018-01-24 Last updated: 2018-08-20Bibliographically approved

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Jendle, JohanCao, Yang

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