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Alternatives to animal testing in basic and preclinical research of atopic dermatitis
Institute for Pharmacy, Pharmacology & Toxicology, Freie Universität Berlin, Berlin, Germany.
Institute for Pharmacy, Pharmacology & Toxicology, Freie Universität Berlin, Berlin, Germany.
Örebro University, School of Medical Sciences.ORCID iD: 0000-0003-3548-4618
Institute for Pharmacy, Pharmacology & Toxicology, Freie Universität Berlin, Berlin, Germany.
2018 (English)In: Experimental dermatology, ISSN 0906-6705, E-ISSN 1600-0625, Vol. 27, no 5, p. 476-483Article, review/survey (Refereed) Published
Abstract [en]

Atopic dermatitis (AD) is a chronic inflammatory skin disease of increasing prevalence, especially in industrialized countries. Roughly 25% of the children and 1%-3% of adults are affected. Although significant progress has been made in the understanding of the pathogenesis of AD, many aspects remain poorly understood. Moreover, there is a pressing need for improved therapeutic options. Studies to elucidate the pathophysiological pathways of AD and to identify novel therapeutic targets over the last few decades have been conducted almost exclusively in animal models. However, in vitro approaches such as 3D skin disease models have recently emerged due to an increasing awareness of distinct interspecies-related differences that hamper the effective translation of results from animal models to humans. In addition, there is growing political and social pressure to develop alternatives to animal models according to the 3Rs principle (reduction, refinement and replacement of animal models).

Place, publisher, year, edition, pages
Wiley-Blackwell Publishing Inc., 2018. Vol. 27, no 5, p. 476-483
Keywords [en]
3R approach, atopic dermatitis, preclinical dermatology, skin equivalents, skin model
National Category
Dermatology and Venereal Diseases
Identifiers
URN: urn:nbn:se:oru:diva-64718DOI: 10.1111/exd.13498ISI: 000434355700009PubMedID: 29356091Scopus ID: 2-s2.0-85042111814OAI: oai:DiVA.org:oru-64718DiVA, id: diva2:1179478
Note

Funding Agency:

Berlin Brandenburg 3R Research Platform

Available from: 2018-02-01 Created: 2018-02-01 Last updated: 2019-03-25Bibliographically approved

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Gorreja, Frida

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